摘要
目的比较艾司西酞普兰与文拉法辛治疗老年焦虑症的临床疗效与安全性。方法选择该院精神科2017年1月-2019年4月收治的60例老年焦虑症患者,按照随机数字表法分为A组30例与B组30例,A组给予文拉法辛,B组给予艾司西酞普兰,比较临床疗效、焦虑评分、抑郁评分、睡眠质量评分、不良反应发生率。结果临床总有效率A组90.00%,B组96.67%,组间比较差异无统计学意义(χ^2=1.071,P>0.05)。治疗后,观察组、对照组的HAMA评分、HAMD评分、PSQI评分与治疗前相比均明显降低(观察组:t=8.601、8.331、7.855;对照组:t=4.636、4.601、4.209,P<0.05),B组的HAMA评分(10.47±3.19)分、HAMD评分(15.34±2.25)分、PSQI评分(10.41±1.98)分与对照组相比均更低(t=4.386、4.149、4.104,P<0.05)。不良反应发生率A组3.33%,B组0.00%,组间比较差异无统计学意义(χ^2=1.017,P>0.05)。结论艾司西酞普兰与文拉法辛用于老年焦虑症治疗中均具有良好的临床疗效和安全性,但艾司西酞普兰对患者焦虑症状、抑郁症状的缓解作用更加显著,可更好地提高患者的睡眠质量。
Objective To compare the clinical efficacy and safety of escitalopram and venlafaxine in the treatment of senile anxiety.Methods A total of 60 elderly patients with anxiety who were treated in the psychiatric department of the hospital from January 2017 to April 2019 were selected and divided into 30 cases in group A and 30 cases in group B according to the random number table method.Group A was given venlafaxine and group B was given escitalopram and compared for clinical efficacy,anxiety score,depression score,sleep quality score,and incidence of adverse reactions.Results The total clinical effective rate was 90.00%in group A and 96.67%in group B.There was no statistical difference between the groups(χ^2=1.071,P>0.05).After treatment,the HAMA score,HAMD score,PSQI score of the observation group and the control group were significantly lower than those before the treatment(The observation group:t=8.601,8.331,7.855;The control group:t=4.636,4.601,4.209,P<0.05),the HAMA score(10.47±3.19)points,HAMD score(15.34±2.25)points,and PSQI score(10.41±1.98)points of group B were lower than those of the control group(t=4.386,4.149,4.104,P<0.05).The incidence of adverse reactions was 3.33%in group A and0.00%in group B.There was no statistical difference between the groups(χ^2=1.017,P>0.05).Conclusion Both escitalopram and venlafaxine have good clinical efficacy and safety in the treatment of senile anxiety,but escitalopram has a more significant relief effect on patients’anxiety symptoms and depression symptoms,which can be better improve the patient’s sleep quality.
作者
管明
GUAN Ming(Department of Psychiatry,Laiwu Central Hospital of Xinwen Mining Group,Jinan,Shandong Province,271103 China)
出处
《系统医学》
2020年第4期27-29,共3页
Systems Medicine
