摘要
目的分析和探讨标准化抗心衰治疗联合法舒地尔对老年心衰患者临床血浆脑利钠肽水平影响的疗效。方法选取该院2017年5月—2019年5月老年心衰患者120例,作为该次研究的主体,采用“随机数字表”法将其分为对照组(60例)和观察组(60例),对照组患者采用标准化抗心衰治疗,观察组患者在对照组患者的基础上,联合法舒地尔治疗,对比和观察两组患者的治疗效果。结果观察组患者的临床总有效率(93.33%)高于对照组(75.00%)(χ2=7.570,P=0.01);不良反应发生率(6.67%)低于对照组(25.00%)(χ2=7.570,P=0.01);左室舒张末期内径(46.51±4.16)mm、左室收缩末期内径(37.62±4.57)mm低于对照组,左室射血分数(49.31±3.27)%高于对照组(χ2=8.520、8.780、9.060,P=0.01);血浆脑利钠肽水平(231.54±12.66)ng/L低于对照组(326.51±13.75)ng/L,6 min最大步行距离(425.15±15.22)m高于对照组(362.61±13.97)m(χ2=39.360、23.450,P=0.01)以上各项均差异有统计学意义(P<0.05)。结论老年心衰治疗中,采用标准化抗心衰联合法舒地尔治疗的效果更佳,不仅能够改善患者心脏功能指标,还能够降低血浆脑利钠肽指标,更好的保护心肌功能。
Objective To analyze and discuss the effect of standardized anti-heart failure treatment combined with fasudil on clinical plasma brain natriuretic peptide levels in elderly patients with heart failure.Methods Patients with senile heart failure(120 cases)were selected as subjects in our hospital(May 2017 to May 2019),and were divided into control group(60 cases)and observation group by"single and double number grouping"method.For example,patients in the control group were treated with standardized an-ti-heart failure,and patients in the observation group were treated with fasudil on the basis of the control group.The therapeutic effects of the two groups were compared and observed.Results The total clinical effective rate of patients in the observation group(93.33%)was higher than that in the control group(75.00%)(χ2=7.570,P=0.01);the incidence of adverse reactions(6.67%)was lower than that in the control group(25.00%)(χ2=7.570,P=0.01);the diameter of the left ventricular end-diastole(46.51±4.16)mm,and the diameter of the left ventricular end-systole(37.62±4.57)mm were lower than those of the control group,and the left ventricular ejection fraction(49.31±3.27)%was higher than that of the control group(χ2=8.520,8.780,9.060,P=0.01);plasma brain natriuretic peptide level(231.54±12.66)ng/L is lower than the control group(326.51±13.75)ng/L,and the maximum walking distance at 6 minutes(425.15±15.22)m was higher than that of the control group(362.61±13.97)m(χ2=39.360,23.450,P=0.01).The above items were statistically significant(P<0.05).Conclusion In the treatment of senile heart failure,the use of standardized anti-heart failure combined with fasudil is better,and on the basis of effectively improving the heart function of patients,it can greatly reduce the level of plasma brain natriuretic peptide and better protect myocardial function.
作者
郭红前
GUO Hong-qian(Taishan Sanatorium,Tai’an,Shandong Province,271000 China)
出处
《世界复合医学》
2020年第2期105-107,共3页
World Journal of Complex Medicine
关键词
标准化抗心衰
法舒地尔
老年心衰
血浆脑利钠肽水平
影响
Standardized anti-heart failure
Fasudil
Senile heart failure
Plasma brain natriuretic peptide level
Effect
