摘要
血管生成参与了多种生理和病理过程,是器官生长和修复的关键,在外科中起着至关重要的作用.目前已有大量关于磁场对血管生成影响的研究报道.本文对现有数据进行总结、分析和比较,包括不同磁场类型、磁场参数、处理方式、处理对象和磁场处理导致的血管生成变化等.由于针对不同磁场参数的系统性研究相对缺乏,目前细胞水平上的研究结果尚无确切的规律.然而动物水平上的研究结果显示,肿瘤组织的血管生成可以被多种磁场所抑制,而长时间或者较高磁场强度的稳态磁场处理非肿瘤组织似乎有促进血管生成的趋势,对此人们还需要进行更系统的研究来进一步确认.此外,本文还讨论了磁场与化疗等其他治疗方法联合使用对血管生成的影响,并总结分析磁场影响血管生成的潜在机制.这不仅有助于人们进一步了解磁场生物学效应,为磁外科技术的安全应用提供实验基础,而且可能为未来将磁场在医学领域的其他潜在应用奠定基础.
This review belongs to a special issue on magnetic surgery(using magnetic field in surgery), which has developed rapidly in the last few years and showed a great potential to be applied in numerous areas. While magnetic surgery has multiple advantages in surgical processes, including but not limited to shorten surgical procedure and duration, reduce inflammation and bleeding, it also adds another exposure source of relatively strong magnetic field to the human bodies. Consequently,concerns were raised regarding the potential adverse effects of these magnets on our bodies. Moreover, people have increased opportunities to be exposed to various magnetic fields generated by magnetic resonance imaging in hospitals,household magnets, cell phones and power lines, therefore, it is essential to investigate the effects of magnetic fields on human bodies.This review focuses on the effects of magnetic fields on the growth of blood vessels, a process known as angiogenesis.Angiogenesis is involved in a variety of physiological and pathological processes including organ growth and repair, and therefore plays important roles not only in surgical related processes, such as postoperative recovery, but also in other processes such as development and tumor growth. Angiogenesis is regulated by a balance between pro-and antiangiogenic signals, which is frequently altered in various malignant, inflammatory, ischemic, infectious, and immune disorders. Many studies have investigated the influence of magnetic field on angiogenesis in the last few decades. Here in this review, we summarize, analyze and compare magnetic field parameters, such as strength, gradient and frequency,experimental procedures, biological samples examined and the detailed experimental results. Although there is still no consensus on the effects at cellular level, which is largely caused by a lack of systematic research on different magnetic field parameters, it is interesting that we found the angiogenesis of tumor tissues can be inhibited by both static and dynamic
作者
朱一鸣
方彦雯
杨建成
纪新苗
方志财
商澎
张欣
Yiming Zhu;Yanwen Fang;Jiancheng Yang;Xinmiao Ji;Zhicai Fang;Peng Shang;Xin Zhang(Institute of Physical Science and Information Technology,Anhui University,Hefei 230601,China;High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China;Heye Health Technology Co.,Ltd.,Huzhou 313300,China;Research&Development Institute of Northwestern Polytechnical University in Shenzhen,Shenzhen 518057,China;Department of Spine Surgery,People’s Hospital of Longhua,Affiliated Hospital of Southern Medical University,Shenzhen 518109,China)
出处
《科学通报》
EI
CAS
CSCD
北大核心
2020年第13期1224-1237,共14页
Chinese Science Bulletin
基金
国家自然科学基金(U1532151)资助。
关键词
稳态磁场
动态磁场
血管生成
磁场强度
肿瘤
static magnetic field
dynamic magnetic field
angiogenesis
magnetic field intensity
tumor
