摘要
缺血再灌注损伤一直是临床面临的重大难题之一。在诸多疾病及外科手术中缺血再灌注损伤都有可能出现,并导致靶器官功能紊乱、移植器官功能丧失,甚至死亡等严重后果。然而,缺血再灌注损伤的作用机制目前尚不清楚,现有观点认为缺血再灌注损伤与钙超载、线粒体损伤、炎性反应、氧化应激反应等有关。而糖代谢又被证实与能量代谢有关,参与调控炎症和氧化应激等反应,因此,在缺血再灌注损伤过程中必然伴随着糖代谢状态的改变。本文通过对缺血再灌注损伤中糖代谢的变化、作用研究现状及进展进行总结,期望为治疗缺血再灌注损伤提供新的方法和策略。
Ischemia-reperfusion injury(IRI)has been always a critical challenge that can cause severe consequences such as organ dysfunction,graft failure,even death in several conditions.Nevertheless,the underlying mechanism remains to be further explored.Currently the leading views with respect that IRI is related to calcium overload,mitochondrial injury,inflammatory cascade,and oxidative stress.Meantime,glucose metabolism plays a critical role in energetic metabolism,participates in inflammatory response and oxidative stress.Therefore,glucose metabolism disorder is inevitable during IRI.This review highlights the current mechanistic insights and progresses to the change and effect of glucose metabolism in IRI,expected to offer novel ideas and strategies in treating IRI.
作者
张旭阳
王容
余曦
李继维
杨龙灿
潘宁波(综述)
张莹(审校)
ZHANG Xuyang;WANG Rong;YU Xi;LI Jiwei;YANG Longcan;PAN Ningbo;ZHANG Ying(The Graduate School,Zunyi Medical University,Zunyi,Guizhou 563000,China;Department of Health Management,Zunyi Medical and Pharmaceutical College,Zunyi,Guizhou 563000,China;Department of Emergency Surgery,Guizhou People's Hospital,Guiyang,Guizhou 550000,China;General Surgery,Bijie First People's Hospital,Bijie,Guizhou 551700,China;Department of Hepatobiliary Surgery,Tongren People's Hospital,Tongren,Guizhou 554300,China;Department of Hepatobiliary Surgery,Guizhou People's Hospital,Guiyang,Guizhou 550000,China)
出处
《重庆医学》
CAS
2020年第10期1702-1705,1714,共5页
Chongqing medicine
基金
贵州省留学人员科技创新项目(黔人项目资助合同[2016]21号)
贵州省科技计划项目(黔科基础[2016]1088)
贵州省卫生和计划生育委员会科学技术基金项目(gzwjkj2018-1-046)。
关键词
缺血再灌注损伤
糖代谢
活性氧
氧化应激
ischemia-reperfusion injury
glucose metabolism
oxidative stress
reactive oxygen species
