摘要
目的:分析2019新型冠状病毒(2019 novel coronavirus,2019-nCoV)肺炎患者(以下简称新冠肺炎)的临床特征。方法:回顾性收集南通市第三人民医院隔离病房2020年1月23日—2月10日收治的26例新冠肺炎患者的一般资料、临床资料、实验室检查、治疗措施及预后。结果:(1)共纳入新冠肺炎患者26例,其中有直接武汉接触史17例(65.38%),平均年龄(47.85±13.11)岁,平均体质量指数(25.09±3.44)kg/m2,有基础疾病患者10例(38.46%)。(2)26例患者中,轻型4例(15.38%),普通型20例(76.92%),重型2例(7.69%),暂无危重型。发热25例(96.15%),以中低热为主;咳嗽20例(73.08%),乏力16例(61.54%),肌肉酸痛13例(50.00%),头痛9例(34.62%)。影像学表现以双肺受累为主(76.92%)。(3)所有患者白细胞总数正常或减少,淋巴细胞减少6例(23.08%),C-反应蛋白升高17例(65.38%),血沉增快22例(84.62%),降钙素原升高1例(3.85%),乳酸脱氢酶增高13例(50.00%)。(4)使用高流量吸氧2例(7.69%),无创呼吸机辅助通气4例(15.38%),所有患者均使用洛匹那韦/利托那韦、α-干扰素及阿比多尔联合抗病毒,目前已有5例(19.23%)好转出院。结论:本研究新冠肺炎患者以普通型为主,临床症状及实验室检查与武汉地区类似,经规范治疗,预后良好。但目前二代病例呈增多趋势,需加强防控。
Objective:To describe the clinical characteristics of 26 cases of 2019 novel coronavirus(2019-nCov)-infected pneumonia.Methods:In this retrospective single-centre study,we included all confirmed cases of NCIP in Nantong Third People′s Hospital from Jan 23 to Feb 10,2020.Cases were confirmed by diagnosis and treatment of NCIP(trial version 5)and were analysed for epidemiological,demographic,clinical,and radiological features and laboratory data.Results:(1)26 patients had been admitted and 17(65.38%)of them had exposed to Wuhan City.The average age was(47.85±13.11)years and the mean body mass index was(25.09±3.44)kg/m2.10(38.46%)had underlying diseases.(2)Among the 26 patients,4(15.38%)were mild,20(76.92%)were normal,and 2(7.69%)were severe.Common symptoms at onset of illness were fever(96.15%),mainly moderate and low fever,followed by cough(73.08%),fatigue(61.54%),muscle pain(50.00%),and headache(34.62%).Radiological featureswere mainly bilateral lung involvement(76.92%).(3)White blood cells were normal or decreased in all patients,lymphocyte count was decreased in 6(23.08%),C-reactive protein was increased in 17(65.38%),erythrocyte sedimentation rate was increased in 22(84.62%),procalcitonin was increased in only 1(3.85%),and lactate dehydrogenase was increased in 13(50.00%).(4)2(7.69%)patients were treated with high-flow oxygen and 4(15.38%)were treated with non-invasive ventilator assisted ventilation.All patients were treated with lopinavir/litonavir,interferon-αand arbidol combined with antiviral therapy.5(19.23%)patients have been discharged from hospital.Conclusion:The newly admitted NCIP patients in our hospital were mainly of the normal type,with clinical symptoms and laboratory examination similar to those in Wuhan City.However,the second-generation cases are increasing,so prevention and control issues should be strengthened.
作者
田李均
徐俊贤
李晗
薛红
王娟
张晓芳
陆雪峰
明芳
韩旭东
TIAN Lijun;XU Junxian;LI Han;XUE Hong;WANG Juan;ZHANG Xiaofang;LU Xuefeng;MING Fang;HAN Xudong(Department of Intensive Care Unit,Nantong Third People′s Hospital,Jiangsu Province,Nantong 226006;Department of Infectious Disease,Nantong Third People′s Hospital,Jiangsu Province,Nantong 226006)
出处
《南通大学学报（医学版）》
2020年第2期99-102,共4页
Journal of Nantong University(Medical sciences)
基金
南通市卫健委市级重点学科支持项目(wx2017002)
南通市科技计划项目(MS12018040)。
关键词
2019新型冠状病毒肺炎
临床特征
流行病学调查
2019 novel coronavirus pneumonia
clinical characteristics
epidemiological investigation
