摘要
目的:探讨卡泊三醇联合沙丁胺醇对银屑病患者血清Th1/Th2型细胞因子水平的影响。方法:选取2017年4月-2019年3月本院收治的银屑病患者100例,依据治疗方案的不同将其分为对照组与研究组,每组50例。对照组患者应用沙丁胺醇进行治疗,研究组使用卡泊三醇联合沙丁胺醇进行治疗。比较两组患者血清中Th1、Th2细胞因子水平、临床治疗效果以及皮肤屏障功能。结果:治疗前,两组的TNF-α、IFN-γ、IL-10及IL-4水平比较,差异均无统计学意义(P>0.05);治疗后,研究组的TNF-α、IFN-γ水平均低于对照组,IL-10、IL-4水平均高于对照组,差异均有统计学意义(P<0.05)。研究组治疗总有效率为92.0%,显著高于对照组的80.0%,差异有统计学意义(P<0.05)。治疗后,研究组皮肤屏障功能各指标水平均优于对照组,差异均有统计学意义(P<0.05)。结论:在银屑病患者的临床治疗中,应用卡泊三醇联合沙丁胺醇联合方案进行治疗,可以有效调节血清中Th1/Th2型细胞因子偏移现象,同时能改善患者皮肤屏障功能各指标水平,临床治疗效果理想,可考虑普及。
Objective:To investigate the effects of Calcipotriol combined with Salbutamol on serum Th1/Th2 cytokines in patients with psoriasis.Method:A total of 100 patients with psoriasis admitted to our hospital from April 2017 to March 2019 were selected,they were divided into control group and study group depending on the treatment regimen,50 cases in each group.The control group was treated with Salbutamol,the control group was given Calcipotriol combined with Salbutamol.The serum levels of Th1 and Th2 cytokines,clinical treatment effect and skin barrier function in the two groups were compared.Result:Before the treatment,the levels of TNF-α,IFN-γ,IL-10 and IL-4 in the two groups were compared,the differences were not statistically significant(P>0.05).After treatment,the levels of TNF-αand IFN-γin the study group were lower than those in the control group,the levels of IL-10 and IL-4 were higher than those in the control group,the differences were statistically significant(P<0.05).The total response rate in the study group was 92.0%,significantly higher than 80.0%in the control group,the difference was statistically significant(P<0.05).After treatment,each index level of skin barrier function in the study group was better than those in the control group,the differences were statistically significant(P<0.05).Conclusion:In the clinical treatment of patients with psoriasis,the application of Calcipotriol combined with Salbutamol combined regimen can effectively regulate the migration of Th1/Th2 cytokines in the serum,and improve the levels of various indicators of skin barrier function of patients.The clinical treatment effect is ideal,which can be considered for popularization.
作者
董颖
靳卓
王博
DONG Ying;JIN Zhuo;WANG Bo(Jiamusi Central Hospital,Jiamusi 154002,China;不详)
出处
《中国医学创新》
CAS
2020年第10期101-104,共4页
Medical Innovation of China
