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尿激酶静脉溶栓治疗对急性缺血性脑卒中患者NIHSS评分的影响 被引量:6

Effects of Urokinase Intravenous Thrombolytic Therapy on NIHSS Scores in Patients with Acute Ischemic Stroke
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摘要 目的:探讨尿激酶静脉溶栓治疗对急性缺血性脑卒中患者美国国立卫生研究院卒中量表(NIHSS)评分的影响。方法:选取2017年2月-2019年2月于本院治疗的82例急性缺血性脑卒患者,按随机数字表法分为研究组和对照组,各41例。对照组进行常规治疗,研究组在对照组基础上进行尿激酶静脉溶栓治疗。比较两组治疗效果、生活质量、神经功能、血清脂蛋白相关磷脂酶A2(Lp-PLA2)、超敏C反应蛋白(hs-CRP)及并发症发生情况。结果:研究组治疗总有效率高于对照组(P<0.05);治疗后,研究组各项生活质量评分均高于对照组(P<0.05);治疗后,研究组Epworth嗜睡量表(ESS)与NIHSS评分均低于对照组(P<0.05);治疗后,研究组血清Lp-PLA2、hs-CRP水平均低于对照组(P<0.05);研究组并发症发生率低于对照组(P<0.05)。结论:尿激酶静脉溶栓治疗急性缺血性脑卒中患者效果理想,可减轻神经功能缺损,降低血清Lp-PLA2、hs-CRP水平,改善患者生活质量,值得临床推广和应用。 Objective:To investigate the effect of urokinase intravenous thrombolytic therapy on the national institute of health stroke scale(NIHSS)score of patients with acute ischemic stroke.Method:A total of 82 patients with acute ischemic stroke treated in our hospital from February 2017 to February 2019 were selected.They were divided into study group and control group according to the random number table method,41 cases in each group.The control group was treated with routine treatment,and the study group was treated with Urokinase intravenous thrombolysis on the basis of the control group.The treatment effect,quality of life,nerve function,serum lipoprotein-associated phospholipase A2(Lp-PLA2),high sensitivity C-reactive protein(hs-CRP)and incidence of complications were compared between the two groups.Result:The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,all scores of life quality in the study group were higher than those in the control group(P<0.05).After treatment,the Epworth somnolence scale(ESS)and NIHSS scores in the study group were lower than those in the control group(P<0.05).After treatment,serum levels of Lp-PLA2 and hs-CRP in the study group were lower than those in the control group(P<0.05).The incidence of complications in the study group was lower than that in the control group(P<0.05).Conclusion:Urokinase intravenous thrombolysis has an ideal effect on patients with acute ischemic stroke,which can alleviate neurological function defects,reduce serum Lp-PLA2 and hs-CRP levels and improve patients’quality of life,it is worthy of clinical promotion and application.
作者 陈志强 袁英翘 林进光 郑精选 文学 林涛 CHEN Zhiqiang;YUAN Yingqiao;LIN Jin’guang;ZHENG Jingxuan;WEN Xue;LIN Tao(Yangjiang People’s Hospital,Yangjiang 529500,China;不详)
出处 《中国医学创新》 CAS 2020年第11期13-17,共5页 Medical Innovation of China
基金 阳江市科学技术局科技项目(社发[2017]05)。
关键词 尿激酶 静脉溶栓 急性缺血性脑卒 NIHSS评分 Urokinase Intravenous thrombolysis Acute ischemic stroke NIHSS score
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