摘要
目的对奥克梯隆型人参皂苷的制备、结构改造及药理活性研究进展进行了综述,为奥克梯隆型人参皂苷的深入研究和进一步开发利用提供参考。方法查阅国内外关于奥克梯隆型人参皂苷研究的相关文献,并进行归纳、总结。结果奥克梯隆型人参皂苷具有良好的抗成瘾、抗心肌缺血、抗肿瘤和抗菌等作用,其结构修饰的研究主要集中在抗菌方面。结论对该类化合物的研究仍有很大的空间与潜力,因此,奥克梯隆型化合物可作为先导物,进行更深入的讨论。
Objective To summarize the preparation,modification and biological evaluation of ocotillol-type ginsenosides and to provide a reference for further research and utilization.Methods The domestic and abroad literatures on ocotillol-type ginsenosides in preparation,modification and biological evaluation were summarized.Results Ocotillol-type ginsenoside has a variety of good pharmacological effects such as anti-addiction,anti-myocardial ischemia,anti-tumor and antibacterial activity.The structural modification was mainly focused on the antibacterial activity.Conclusion There are still large space and potential in the research of ocotillol-type compounds.Therefore,ocotillol-type compounds can be used as leads for further research in future.
作者
周志文
周云云
ZHOU Zhiwen;ZHOU Yunyun(Medical College of China Three Gorges University,Yichang 443002,China;China Resources Sanjiu(Huangshi)Medical&Pharmaceutical Limited Company,Huangshi 435000,China)
出处
《西北药学杂志》
CAS
2020年第3期449-454,共6页
Northwest Pharmaceutical Journal
基金
三峡大学高层次人才科研启动基金项目(编号:8000303)。
关键词
奥克梯隆
人参皂苷
结构改造
药理活性
ocotillol
ginsenosides
structural modification
pharmacological activity
