摘要
目的应用静息态功能磁共振(rsf MRI)技术和局部一致性(Re Ho)分析方法对伴有妄想症状的阿尔茨海默病(AD)患者的影像学特征进行研究。方法选取32例AD患者和16名正常老年人(HC组)。AD患者根据痴呆行为量表(BEHAVE-AD)和精神神经科问卷(NPI)再分为伴有妄想症状的AD患者(AD-D组,16例)和无妄想症状的AD患者(AD-noD组,16例)。对照组、AD-D组和AD-noD组分别行头颅rsf MRI检查,采用Re Ho方法分析,比较三组脑影像学差异性。结果单因素方法分析三组之间Re Ho差异性脑区在右侧颞中回、中央后回和左额下回(P<0.05);相对于HC组,AD-noD组右侧颞中回、中央后回Re Ho降低(P<0.05);相对于HC组,AD-D组左额下回Re Ho降低(P<0.05),右侧颞中回和中央后回Re Ho升高(P<0.05);相对于AD-noD组,AD-D组左额下回Re Ho降低(P<0.05),右侧颞中回Re Ho升高(P<0.05)。结论伴有妄想症状的AD患者存在颞叶、额叶大脑新皮质的功能损伤。
Objective To investigate the delusions in patients with Alzheimer’s disease(AD)by measuring the regional homogeneity(ReHo)in resting-state functional magnetic resonance imaging(rs-fMRI).Methods 32 AD patients and 16 healthy elderly controls(HC group)were selected and these 32 AD patients were further divided into AD patients with delusion(AD-D group,16 cases)and AD patients without delusion(AD-noD group,16 cases)by Behavioral Pathology in Alzheimer’s Disease(BEHAVE-AD)and Neuropsychiatric Inventory(NPI).All the three groups separately received fMRI scan in resting state and were compared by analysis of ReHo.Results The ReHo differential brain region among three groups were right middle temporal gyrus(MTG),right postcentralgyrus(PoCG)and left inferior frontal gyrus(IFG)(P<0.05).Compared with HC group,AD-noD group had decreased ReHo in right MTG and right PoCG(P<0.05);compared with HC group,AD-D group had decreased ReHo in left IFG(P<0.05),meanwhile increased ReHo in right MTG and right PoCG(P<0.05).Compared with AD-noD group,AD-D group had decreased ReHo in left IFG(P<0.05)and increased ReHo in right MTG(P<0.05).Conclusion The AD patients with delusion may have function impairment in cerebral neocortex of temporal lobe and frontal lobe.
作者
郭忠伟
朱红
张震中
魏福全
刘小征
陈炜
GUO Zhongwei;ZHU Hong;ZHANG Zhenzhong(Zhejiang Mental Health Center,Hangzhou 310012,China)
出处
《精神医学杂志》
2019年第5期352-356,共5页
Journal of Psychiatry
基金
浙江省医药卫生科技计划项目(编号:2018KY031)。
关键词
阿尔茨海默病
妄想
静息态功能性磁共振
局部一致性
Alzheimer’s disease
Delusions
Resting-state functional magnetic resonance imaging
Regional homogeneity
