摘要
军事、公共安全和应急救援等对现场、实时、准确、快速检测技术提出了迫切需求。敞开式离子化质谱技术可以现场直接分析样品,具有简单、快速、无需样品前处理、可分析多种相态物质的特点。本文总结了基于激光、等离子体和电喷雾原理的敞开式离子化技术的研究进展,介绍了敞开式离子化质谱技术在化学战剂、生物和爆炸物检测领域的应用,并对敞开式离子化质谱技术面临的问题和未来研究方向进行了总结与展望。
Military, public safety and emergency rescue have put forward an urgent need for the technology of on-site, real-time, accurate and rapid detection. Ambient ionization mass spectrometry can directly analyze sample on-site, and it has characteristics of simplicity, fast, no sample preparation and can be used to analyze gaseous, liquid and solid sample. The research development of ambient ionization technology was summarized in this paper. In the section of laser desorption/ionization source, the research development and application of four ionization source were introduced, including electrospray assisted laser desorption ionization, laser ablation electrospray ionization, laser-induced acoustic desorption electrospray ionization and plasma-assisted laser desorption ionization. In the content of plasma ionization source, the low temperature plasma(LTP) probe was introduced. The protein and peptide could be detected using paper-based analytical devices(PADs) coupled with LTP. In order to solve the floating potential problem in the plasma, the symmetrical or T-shape DBDI was researched. The miniatured LTP was researched aiming to decrease the high voltage in the plasma. In the electrospray ionization source part, the paper spray and syringe spray ionization were introduced, such as detecting some medicines and bacteria. The application of ambient ionization technology in the detection of chemical warfare agents, biology and explosives was introduced. In the part of chemical warfare agents(CWAs) detection, the microhollow cathode discharge plasma ionization source, and the plasma ionization source coupled with mass spectrometry in the lab and the Mini 10.5 to analyze highly toxic nerve agents(G-series, V-series) and blistering warfare agents and the stimulants were introduced. On the basis of plasma-PADs, gold nanoparticles-enhanced ion-transmission mass spectrometry for highly sensitive detection of CWAs was introduced. In the biology detection content, membrane electrospray ionization source coupled with miniature
作者
李宝强
张众垚
孔景临
张琳
郭成海
李翠萍
LI Bao-qiang;ZHANG Zhong-yao;KONG Jinglin;ZHANG Lin;GUO Cheng-hai;LI Cui-ping(State Key Laboratory of NBC Protection for Civilian,Institute of Chemical Defense of the Acade4y of Military Science of PLA,Beijing 102205,China)
出处
《质谱学报》
EI
CAS
CSCD
北大核心
2020年第3期221-235,I0001,共16页
Journal of Chinese Mass Spectrometry Society
基金
国家自然科学基金项目(61775017)资助。
关键词
敞开式离子化
小型质谱
化生爆检测
ambient ionization
miniature mass spectrometry
CBE detection
