摘要
表没食子儿茶素-3-没食子酸酯(epigallocatechin-3-gallate,EGCG)具有抗菌、抗炎、抗肿瘤等多种作用,EGCG对于口腔癌的防治及其抗癌机制的探究是研究热点,本文就EGCG对于口腔癌的防治作用及其抗癌机制做一综述,研究显示,EGCG可以调控多条细胞代谢信号通路,如G蛋白偶联受体信号通路、丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路、Wnt信号通路,并且可以调控DNA甲基化与作用于口腔癌细胞的RNA中,直接或间接通过口腔癌细胞信号传导网络抑制口腔癌前病变及口腔癌的发生发展。EGCG与5-氟尿嘧啶联合应用能够增强疗效,降低副作用,有望作为预防和治疗口腔癌的新型药物。
Epigallocatechin-3-gallate(EGCG)has antibacterial,anti-inflammatory,antitumor,and other functions.EGCG and its anticancer mechanism are hot research topics in the prevention and treatment of oral cancer.In this pa-per,the prevention and treatment effects of EGCG on oral cancer and its anticancer mechanism are reviewed.The re-sults show that EGCG can regulate multiple cell metabolic signaling pathways,such as the G protein coupled receptor signaling pathway,mitogen-activated protein kinase(MAPK),and the Wnt signaling pathway,and it can regulate DNA methylation and act on RNA of oral cancer cells directly or indirectly through the oral cancer cell signal transduction network to inhibit the development of oral precancerous lesions and oral cancer.EGCG combined with 5-fluorouracil can enhance the curative effect and reduce adverse effects and is expected to be a new drug for the prevention and treat-ment of oral cancer.
作者
刘恩言
贺兵
李明云
LIU Enyan;HE Bing;LI Mingyun(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《口腔疾病防治》
2020年第7期468-471,共4页
Journal of Prevention and Treatment for Stomatological Diseases
基金
国家自然科学基金青年项目(81400501、81500811)。
