摘要
目的探讨人B淋巴细胞刺激因子(BAFF)和白细胞介素-4(IL-4)在毒性弥漫性甲状腺肿(Graves病)发病机制中的作用,评估BAFF、IL-4对Graves病的诊断预测价值。方法选取2018年12月至2019年6月蚌埠医学院第一附属医院内分泌科收治的Graves病患者58例(GD组),其中新发者33例(GD1组),治愈者25例(GD2组);选取同期健康体检者27例作为对照(N组)。检测研究对象血清BAFF、IL-4和甲状腺功能等指标。结果GD组患者血清中BAFF、IL-4表达水平较N组明显上调,且GD1组较N组上调更加明显,GD1组患者血清中BAFF、IL-4表达水平较GD2组明显上调,差异均有统计学意义(P<0.05)。GD1组患者血清中BAFF、IL-4表达水平与促甲状腺激素受体抗体均具有一定的相关性(r=0.7541、0.6386,P<0.05);GD1组患者血清中BAFF表达水平与IL-4表达水平呈正相关(r=0.4952,P=0.034)。BAFF、IL-4联合诊断Graves病的受试者工作特征曲线下面积为0.889,BAFF、IL-4对Graves病均具有一定的诊断价值。结论Graves病患者血清中BAFF、IL-4表达水平高于健康者,且二者表达水平与促甲状腺激素受体抗体显著相关,说明BAFF、IL-4与Graves病的发病机制相关。
Objective To investigate the role of human B cell-activating factor(BAFF)and interleukin-4(IL-4)in the pathogenesis of Graves′disease,and to evaluate the diagnostic and predictive value of BAFF and IL-4 in Graves′disease(GD).Methods Fifty-eight patients with GD(GD group)admitted to the endocrinology department of this hospital from December 2018 to June2019 were selected,including 33 newly diagnosed cases(GD1 group),25 cured cases(GD2 group);contemporaneous 27 persons undergoing healthy physical examination were selected as the control group(N group).Serum BAFF and IL-4 levels and thyroid function indicators were detected in the study subjects.Results The expression levels of serum BAFF and IL-4 in the GD group were significantly up-regulated compared with those in the N group,moreover which in the GD1 group were significantly up-regulated compared with those in GD2 group,and the difference was statistically significant(P<0.05).The expression levels of serum BAFF and IL-4 in the GD1 group had a certain correlation with thyrotrophin receptor antibody(TRAb)(r=0.7541,0.6386,P<0.05);and there was a correlation between the BAFF expression level and IL-4 expression level in the GD1 group(r=0.4952,P=0.034).The area under the receiver operating characteristic curve(AUC)of BAFF and IL-4 for the joint diagnosis of GD was0.889.BAFF and IL-4 all had a certain diagnostic value in GD.Conclusion The expression levels of serum BAFF and IL-4 in the patients with GD are higher than those in healthy persons,moreover their expression levels are significantly correlated with TRAb,indicating that BAFF and IL-4 are correlated with the pathogenesis of GD.
作者
王丹
毕娅欣
徐二琴
金国玺
WANG Dan;BI Yaxin;XU Erqin;JIN Guoxi(Department of Endocrinology,First Affiliated Hospital of Bengbu Medical College,Bengbu,Anhui 233004,China;Teaching and Researching Section of Diagnostics,Bengbu Medical College,Bengbu,Anhui 233004,China)
出处
《现代医药卫生》
2020年第10期1448-1451,1454,共5页
Journal of Modern Medicine & Health
基金
安徽省蚌埠市科技局科技指导项目(20160328)。
