摘要
【目的】观察小建中胶囊联合耳穴压豆治疗脾胃虚寒证十二指肠溃疡的临床疗效与安全性。【方法】将68例脾胃虚寒证十二指肠溃疡患者随机分为试验组与对照组,每组各34例。对照组给予口服奥美拉唑肠溶胶囊治疗,试验组在对照组基础上给予口服小建中胶囊联合耳穴压豆治疗,疗程为4周。观察2组患者治疗前后中医证候评分的变化情况,评价2组患者的临床疗效、复发情况及安全性。【结果】(1)治疗4周后,试验组的总有效率为97.1%(33/34),对照组为79.4%(27/34)。试验组的临床疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的中医证候评分均较治疗前明显降低(P<0.01),且试验组的降低作用明显优于对照组,差异有统计学意义(P<0.01)。(3)治疗结束后3个月,试验组的复发率为8.82%(3/34),对照组为35.29%(12/34),试验组的复发率明显低于对照组,差异有统计学意义(P<0.01)。(4)治疗过程中,2组患者均无严重的不良反应情况发生。【结论】小建中胶囊联合耳穴压豆治疗脾胃虚寒证十二指肠溃疡的临床疗效确切。
Objective To observe the clinical efficacy and safety of Xiao Jianzhong Capsules combined with auricular point seed-pressing therapy in the treatment of duodenal ulcer with spleen and stomach deficiency-cold syndrome. Methods Sixty-eight duodenal ulcer patients with the syndrome of spleen and stomach deficiency-cold were randomly divided into trial group and control group,each group having 34 cases. The patients of the control group were treated with omeprazole enteric capsules orally,and the patients of the trial group were treated with omeprazole enteric capsules and Xiao Jianzhong Capsules orally together with auricular point seed-pressing therapy. The treatment course for the two groups lasted 4 weeks. The scores of traditional Chinese medicine(TCM)syndrome in the two groups were observed before and after treatment,and the clinical efficacy,recurrence rate,and clinical safety in the two groups were also evaluated. Results(1)After 4 weeks of treatment, the total effective rate of the trial group was 97.1% and the total effective rate of the control group was 79.4%,indicating that the clinical efficacy of the trial group was superior to that in the control group, and the difference was statistically significant(P<0.05).(2)After treatment, the scores of TCM syndrome in the two groups were obviously decreased in comparison with those before treatment(P<0.01),and the decrease in the trial group was superior to that in the control group,the difference being statistically significant(P<0.01).(3)Three months after treatment,the recurrence rate in the trial group was 8.82%,lower than that in the control group(35.29%),and the difference was statistically significant(P<0.01).(4) During the trial, no severe adverse reaction occurred in the two groups. Conclusion Xiao Jianzhong Capsules combined with auricular point seed-pressing therapy have certain effect in treatment of duodenal ulcer with spleen and stomach deficiency-cold syndrome.
作者
邓晓敏
林燕端
傅诗书
DENG Xiao-Min;LIN Yan-Duan;FU Shi-Shu(Bao'an Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine,Shenzhen 518000 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2020年第6期1035-1039,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
小建中胶囊
耳穴压豆
脾胃虚寒证
十二指肠溃疡
临床疗效
Xiao Jianzhong Capsules
auricular point seed-pressing therapy
spleen and stomach deficiency-cold syndrome
duodenal ulcer
clinical efficacy
