摘要
目的总结肿瘤微环境中整合素、肿瘤代谢和肿瘤细胞与胰腺星状细胞的关系,旨在为胰腺导管腺癌的治疗及药物研发提供靶点和思路。方法对国内外以胰腺星状细胞、整合素、氨基酸代谢等作为胰腺导管腺癌治疗靶点的研究文献进行综述。结果针对胰腺导管腺癌的靶向药物研究目前正蓬勃开展,但均停留在动物及临床试验阶段。ProAgio作为一种新的治疗性蛋白,对胰腺导管腺癌微环境中整合素αvβ3的表达、胰腺星状细胞的活化及其分泌、丙氨酸代谢等具有抑制作用,从而达到抗纤维化及抗肿瘤的双重作用。结论活化的胰腺星状细胞、ProAgio、整合素αvβ3、丙氨酸代谢等在胰腺导管腺癌中的作用已部分阐明,但具体作用机制仍需进一步研究,并可能成为全新的治疗靶点。
Objective To summarize the relationship between integrins,tumor metabolism,and tumor cells with pancreatic stellate cells in the tumor microenvironment,in order to provide targets and ideas for the treatment of pancreatic ductal adenocarcinoma. Method To review the literatures on pancreatic stellate cells,integrins,and amino acid metabolism as therapeutic targets for pancreatic ductal adenocarcinoma in the domestic and overseas. Results The drug research for pancreatic ductal adenocarcinoma was currently under vigorous development,but remain in the animal and clinical test stage. As a new therapeutic protein,ProAgio could inhibit the expression of integrin αvβ3,activation and secretion of pancreatic stellate cells,and alanine metabolism in the microenvironment of pancreatic ductal adenocarcinoma,so as to achieve the dual effects of anti-fibrosis and anti-tumor. Conclusions The roles of activated pancreatic stellate cells,ProAgio,integrin αvβ3,and alanine metabolism in pancreatic ductal adenocarcinoma have been partially elucidated,but the specific mechanism still needs further investigation and may become a completely new therapeutic target someday.
作者
郑万明
吴兴浪
游海波
龚建平
ZHENG Wanming;WU Xinglang;YOU Haibo;GONG Jianping(Department of General Surgery,Chongqing Traditional Chinese Medicine Hospital of Yubei District,Chongqing 401120,P.R.China;Department of Hepatobiliary Surgery,The Second Affiliated Hospital of Chongqing Medical University.Chongqing 400010,P.R.China;Department of Hepatobiliary Surgery,People’s Hospital of Changshou,Chongqing 401220,P.R.China)
出处
《中国普外基础与临床杂志》
CAS
2020年第5期619-623,共5页
Chinese Journal of Bases and Clinics In General Surgery
基金
2016年度重庆市社会民生科技创新专项(项目编号:cstc2016shmszx130041)
重庆市卫生计生委2017年医学科研计划项目(项目编号:2017MSXM145)。
关键词
ProAgio
整合素
胰腺星状细胞
肿瘤微环境
肿瘤代谢
胰腺导管腺癌
综述
ProAgio
integrin
pancreatic stellate cell
tumor microenvironment
tumor metabolism
pancreatic ductal adenocarcinoma
review
