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噻托溴铵吸入剂治疗稳定期D组慢性阻塞性肺疾病疗效分析 被引量:19

Efficacy analysis of tiotropium bromide inhalant in the treatment of COPD in stable period D group
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摘要 目的:探讨噻托溴铵吸入剂对稳定期D组慢性阻塞性肺疾病(COPD)病人临床症状、肺功能及其生活质量的改善作用。方法:选取92例稳定期D组(按GOLD 2018分组) COPD病人为研究对象,依据随机数字表法分为观察组(n=46)和对照组(n=46)。对照组行肺功能锻炼及布地奈德/福莫特罗吸入治疗,观察组在对照组基础上联合噻托溴铵吸入剂治疗,治疗6个月后比较2组病人6 min步行距离(6MWD)、肺功能(FEV1、FVC)、临床症状评分(CAT)、呼吸困难程度(mMRC评分)、生活质量(SGRQ评分)。结果:2组病人FEV1、FVC治疗后较治疗前均改善,观察组高于对照组(P <0. 01);2组6MWD均较治疗前改善,且观察组高于对照组(P <0. 01);治疗后2组病人CAT、mMRC、SCRQ评分均减少,观察组改善优于对照组(P <0. 01)。结论:肺功能锻炼联合噻托溴铵及布地奈德/福莫特罗治疗稳定期D组COPD病人能有效改善病人的临床症状及肺功能,提高病人的生活质量。 Objective:To investigate the effects of tiotropium bromide inhalant on clinical symptoms,pulmonary function and quality of life in patients with chronic obstructive pulmonary disease(COPD)in stable group D.Methods:Ninety-two patients with stable COPD in group D(according to GOLD 2018)were randomly divided into the observation group(n=46)and control group(n=46).The control group was treated with function exercise and budesonide/formoterol inhalation,and the observation group was treated with tiotropium bromide inhalant on the basis of the control group.After six months of treatment,the lung function(FEV1 and FVC),six-minute walking distance(6MWD),clinical symptom score(CAT),dyspnea degree(mMRC score),quality of life(SGRQ score)were compared between two groups.Results:After treatment,the FEV1 and FVC in two groups were improved compared with those before treatment,and the FEV1 and FVC in observation group were higher than those in control group(P<0.01).After treatment,the 6MWD in two groups was improved compared with that before treatment,and the 6MWD in observation group was higher than that in control group(P<0.01).After treatment,the scores of the CAT,mMRC and SGRQ reduced,and the improvement degree in observation group was better than that in control group(P<0.01).Conclusions:Tiotropium bromide inhalant combined with pulmonary function exercise and budesonide/formoterol in treating the stable COPD in group D can effectively improve the symptoms,pulmonary function and quality of life of patients.
作者 何艳 钱朝霞 方陈 陈永 吴龙云 HE Yan;QIAN Zhao-xia;FANG Chen;CHEN Yong;WU Long-yun(Department of Respiratory,The Third People′s Hospital of Bengbu,Bengbu Anhui 233000,China)
出处 《蚌埠医学院学报》 CAS 2020年第4期489-492,共4页 Journal of Bengbu Medical College
关键词 慢性阻塞性肺疾病 噻托溴铵 肺功能锻炼 chronic obstructive pulmonary disease tiotropium pulmonary function exercise
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