摘要
目的探讨乙酰半胱氨酸联合丙酸倍氯米松雾化吸入治疗毛细支气管炎的临床效果。方法选取2018年2月~2019年2月我院收治的306例毛细支气管炎患儿作为研究对象,按照电子病历的自然排序,将其分为治疗A组(106例)、治疗B组(100例)和对照组(100例)。所有患儿均给予常规治疗措施。治疗A组患儿采用乙酰半胱氨酸联合丙酸倍氯米松雾化吸入治疗。治疗B组患儿采用丙酸倍氯米松联合沙丁胺醇雾化吸入治疗。对照组患儿采用沙丁胺醇雾化吸入治疗。比较三组患儿的喘息、喘鸣音、三凹征消失时间,观察三组患儿的治疗效果及不良反应发生情况。结果治疗A组患儿的喘息、喘鸣音及三凹征消失时间均短于治疗B组和对照组,治疗B组患儿的喘息、喘鸣音及三凹征消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗A组患儿的治疗总有效率高于治疗B组和对照组,差异均有统计学意义(P<0.05)。治疗B组和对照组患儿的治疗总有效率比较,差异无统计学意义(P>0.05)。三组患儿治疗过程中均未发生严重不良反应。结论采用乙酰半胱氨酸联合丙酸倍氯米松雾化吸入治疗毛细支气管炎,可缩短患儿的临床症状消失时间,提高临床治疗效果,不良反应少,安全性好,值得临床推广应用。
Objective To investigate the clinical effect of aerosol inhalation of Acetylcysteine combined with Beclomethasone Dipropionate in the treatment of capillary bronchitis.Methods A total of 306 patients with capillary bronchitis treated in our hospital from February 2018 to February 2019 were selected as the research subjects.According to the sequence of electronic medical records,they were divided into treatment-A group(n=106),treatment-B group(n=100),and control group(n=100).All children were given routine treatment.In the treatment-A group,aerosol inhalation of Acetylcysteine combined with Beclomethasone Dipropionate was used.In the treatment-B group,aerosol inhalation of Salbutamol combined with Beclomethasone Dipropionate was used.In the control group,aerosol inhalation of Salbutamol alone was applied.The disappearance time of panting,wheezing sound and three concave signs in the three groups was compared.The treatment effect and the occurrence of adverse reactions were observed.Results The disappearance time of panting,wheezing sound and three concave signs in the treatment-A group was shorter than that of the treatment-B group and the control group,the disappearance time of panting,wheezing sound and three concave signs in the treatment-B group was shorter than that in the control group,the differences were statistically significant(P<0.05).The total effectiveness rate in the treatment-A group was higher than that in the treatment-B group and the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total effective rate between the treatment-B group and the control group(P>0.05).No serious adverse reactions occurred during the treatment of the three groups of children.Conclusion Aerosol inhalation of Acetylcysteine combined with Beclomethasone Dipropionate in the treatment of capillary bronchitis can shorten the disappearance time of clinical symptoms,improve the clinical treatment effect in few adverse reactions and good safety,which is worthy of
作者
史军然
杜杰静
高虹
薛晋玲
刘连凤
SHI Jun-ran;DU Jie-jing;GAO Hong;XUE Jin-ling;LIU Lian-feng(The Second Department of Pediatrics,Shijiazhuang Maternal and Child Health Hospital,Hebei Province,Shijiazhuang 050000,China)
出处
《中国当代医药》
2020年第12期90-93,共4页
China Modern Medicine
基金
河北省医学科学研究重点课题计划项目(20150885)。
关键词
毛细支气管炎
雾化吸入
乙酰半胱氨酸
丙酸倍氯米松
Capillary bronchitis
Aerosol inhalation
Acetylcysteine
Beclomethasone Dipropionate
