摘要
目的:观察参麦注射液联合常规西药治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭的临床疗效。方法:将收治的80例AECOPD合并呼吸衰竭患者按随机数字表法分为观察组与对照组各40例,对照组给予常规西药治疗,观察组在对照组基础上给予参麦注射液治疗,疗程结束后评价2组临床疗效。结果:观察组治疗后临床总有效率为87.50%,高于对照组67.50%,差异有统计学意义(P<0.05)。治疗后,2组用力肺活量(FVC)较治疗前降低,第1秒用力呼气容积(FEV1)、FEV1/FVC较治疗前提高,观察组FEV1、FEV1/FVC高于对照组,FVC低于对照组,2组治疗后各项肺功能指标比较,差异有统计学意义(P<0.05)。治疗后,2组动脉二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)水平较治疗前提高,PaCO2水平较治疗前降低,观察组SaO2、PaO2水平高于对照组,PaCO2水平低于对照组,2组治疗后各项血气指标比较,差异有统计学意义(P<0.05)。治疗前,免疫功能指标CD3+、CD4+、CD8+、CD4+/CD8+水平比较,差异无统计学意义(P>0.05);治疗后,2组CD3+、CD4+及CD4+/CD8+水平较治疗前提高,CD8+水平较治疗前降低,观察组CD3+、CD4+及CD4+/CD8+水平高于对照组,CD8+水平低于对照组,2组治疗后各项免疫功能指标比较,差异有统计学意义(P<0.05)。结论:参麦注射液联合常规西药治疗AECOPD合并呼吸衰竭较单纯西药治疗的疗效更显著,并能改善患者肺功能及血气功能指标,提高患者机体免疫力,在AECOPD合并呼吸衰竭患者临床治疗中具有重要价值。
Objective:To observe the clinical effect of Shenmai injection combined with routine western medicine for acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with respiratory failure.Methods:A total of 80 cases of patients with AECOPD complicated with respiratory failure were divided into the observation group and the control group according to the random number table method,40 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with Shenmai injection based on the treatment of the control group.The clinical effect in the two groups was evaluated after treatment.Results:After treatment,the total clinical effective rate was 87.50%in the observation group,higher than that of 67.50%in the control group,the difference being significant(P<0.05).After treatment,the forced vital capacity(FVC)in the two groups were deceased when compared with those before treatment,and the forced expiratory volume in one second(FEV1)and the ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)were increased when compared with those before treatment;FEV1 and FEV1/FVC in the observation group were higher than those in the control group,and FVC was lower than that in the control group;the comparison of each index of the lung function after treatment between the two groups showed significance in the difference(P<0.05).After treatment,the levels of partial pressure of carbon dioxide(PaCO2)and partial pressure of oxygen(PaO2)in arteries in the two groups were increased when compared with those before treatment,and the levels of PaCO2 were decreased when compared with those before treatment;the levels of SaO2 and PaO2 in the observation group were higher than those in the control group,and the level of PaCO2 was lower than that in the control group;the comparison of each index of the blood gas after treatment between the two groups showed significance in the difference(P<0.05).Before treatment,compared the levels
出处
《新中医》
CAS
2020年第8期76-79,共4页
New Chinese Medicine
关键词
慢性阻塞性肺疾病
急性加重期
呼吸衰竭
参麦注射液
中西医结合疗法
Chronic obstructive pulmonary disease
Acute exacerbation
Respiratory failure
Shenmai injection
Integrated Chinese and western medicine therapy
