摘要
目的:定性分析实时剪切波弹性成像(shear wave elastography,SWE)图像上肝局灶性病变(focal liver lesion,FLL)边界和周围肝组织的弹性特征及相关影响因素。方法:选取2012年2月至2013年12月于中山大学附属第一医院就诊的152例FLL患者(152个病灶),所有患者均行FLL及其周围肝组织SWE检查,同时记录其临床及实验室指标,分析FLL的弹性边界(清楚或不清楚)、病变周围肝组织弹性分布类型及两者的影响因素。结果:本研究共纳入良性病变26例,恶性病变126例。良性病变中25例(96.2%)表现为弹性边界清楚,1例(3.8%)表现为弹性边界不清;恶性病变中82例(65.1%)表现为弹性边界清楚,44例(34.9%)表现为弹性边界不清。多因素分析显示,病变良恶性是弹性边界是否清楚的独立影响因素(P<0.05);良、恶性病变周围肝组织弹性分布表现为A型(均匀蓝色)、B型(蓝绿色)、C型(不均匀呈五彩状)分别为20例(76.9%)、6例(23.1%)、0例和17例(13.5%)、60例(47.6%)、49例(38.9%);病变周围肝组织的弹性分布类型(A型、B型、C型)在良恶性病变、有无病毒性肝炎背景、不同性别及不同白蛋白、总胆红素、丙氨酸转氨酶水平之间差异有统计学意义(均P<0.05),而在不同大小病变之间的分布类型差异无统计学意义(P=0.346)。结论:定性分析FLL边界和周围肝组织的弹性特征可为FLL的良恶性鉴别诊断提供参考,FLL边界和周围肝组织弹性特征受病变性质及肝病背景影响,而与病变大小无关。边界弹性特征鉴别诊断不同类型FLL仍需进一步的定量研究。
Objective To qualitatively analyze the elasticity characteristics of boundaries and surrounding liver tissue of focal liver lesions(FLL)by real-time shear wave elastography(SWE),and to analyze the relating influencing factors.Methods One hundred and fifty-two patients with FLLs(152 lesions)from February 2012 to October 2013 in the First Affiliated Hospital of Sun Yat-Sen University were collected.SWE of FLLs and the surrounding liver tissue was performed and baseline clinical data were collected.The elastic boundary(clear or not clear)of FLLs and elasticity distributions of surrounding liver tissue and their influencing factors were analyzed.Results A total of 26 benign lesions and 126 malignant lesions were included in this study.Twenty-five cases(96.2%)of benign lesions showed clear elastic boundaries and 1 case(3.8%)showed unclear elastic boundary while 82 cases(65.1%)of malignant lesions showed clear elastic boundaries and 44 cases(34.9%)showed unclear elastic boundaries.Multivariate analysis showed benign/malignant lesion was an independent influencing factor for elastic boundary(P<0.05).Twenty cases(76.9%),6 cases(23.1%)and 0 case of liver tissue around benign lesions showed type A,B and C elastic distribution respectively while 17 cases(13.5%),60 cases(47.6%),and 49 cases(38.9%)of liver tissue around malignant lesions showed type A,B,and C elastic distribution.There were statistically significant differences of benign and malignant lesions,different viral hepatitis backgrounds,different gender,and different ALB,TBIL,ALT levels in elasticity distributions of surrounding liver tissue of FLLs among type A,B and C(all P<0.05)while there was no significant difference in different lesion size(P=0.036).Conclusions The elasticity characteristics of boundaries and surrounding liver tissue of FLLs on SWE images can provide a reference for differential diagnosis of benign and malignant FLLs.The elastic characteristics of surrounding liver tissue of FLLs are influenced by the nature of lesions and the background of li
作者
钟娴
苏丽娅
谢晓燕
田文硕
龙海怡
林满霞
Zhong Xian;Su Liya;Xie Xiaoyan;Tian Wenshuo;Long Haiyi;Lin Manxia(Department of Ultrasound,the First Affiliated Hospital of Sun Yat-Sen University&Institute of Diagnostic and Interventional Ultrasound,Sun Yat-Sen University,Guangzhou 510080,China)
出处
《中华超声影像学杂志》
CSCD
北大核心
2020年第4期349-353,共5页
Chinese Journal of Ultrasonography
基金
国家自然科学基金青年科学基金(81901768)
国家自然科学基金重点项目(81530055)。
关键词
实时剪切波弹性成像
肝局灶性病变
边界
弹性特征
Real-time shear wave elastography
Focal liver lesion
Boundary
Elasticity characteristic
