摘要
目的:利用Meta分析评价复方玄驹胶囊治疗多囊卵巢综合征不孕症的临床效果。方法:检索CNKI数据库,VIP数据库,万方数据库,中国临床试验注册中心(ChiTRP),Pubmed,Cochrane library,国际临床试验注册协作网(ICTRP)等数据库,纳入复方玄驹胶囊治疗多囊卵巢综合征不孕症的随机对照治疗(RCT),并对纳入文献进行质量评价,采用RevMan5.3软件进行统计分析。结果:14篇RCTs纳入研究共1100名患者,Meta分析结果显示:与对照组相比,复方玄驹胶囊能提高妊娠率[RR=1.68,95%CI(1.45,1.94),P<0.00001],在改善周期排卵率[RR=1.17,95%CI(1.03,1.34),P=0.02]、中医症候[RR=1.6,95%CI(1.28,2.00),P<0.0001]、血清睾酮水平[RR=-0.53,95%CI(-0.90,-0.16),P=0.005]和子宫内膜厚度[RR=1.56,95%CI(1.26,1.86),P<0.00001]均优于对照组。结论:复方玄驹胶囊是治疗多囊卵巢综合征不孕症的有效药物。但尚需更多大样本高质量临床试验予以验证。
Objective:To evaluate the clinical effect of Fufang Xuanju Capsule in treating infertility due to polycystic ovary syndrome using Meta analysis.Methods:Databases such as CNKI database,VIP database,Wanfang database,China Clinical Trial Registration Center (ChiTRP),Pubmed,Cochrane library,and International Trial Registration Collaboration Network (ICTRP) were searched for Fufang Xuanju Capsules for the treatment of polycystic ovary syndrome Randomized controlled treatment (RCT) of infertility,and the quality of the included literature was evaluated,and statistical analysis was performed using RevMan5.3 software.Results:Fourteen RCTs were included in a total of 1100 patients.The meta-analysis results showed that compared with the control group,Fufang Xuanju Capsule can increase the pregnancy rate [RR=1.68,95% CI (1.45,1.94),P <0.00001],In improving cycle ovulation rate [RR=1.17,95% CI (1.03,1.34),P=0.02],TCM symptoms [RR=1.6,95% CI (1.28,2.00),P <0.0001],serum testosterone levels[RR=-0.53,95% CI (-0.90,-0.16),P=0.005] and endometrial thickness [RR=1.56,95% CI (1.26,1.86),P <0.00001] were better than the control group.Conclusion:Fufang Xuanju Capsule is an effective drug for treating polycystic ovary syndrome infertility.However,more large-scale high-quality clinical trials are needed to verify.
作者
杜秀
曹云
DU Xiu;CAO Yun(The First Affiliated Hospital of Guangxi University of Chinese Medicine,Guangxi Nanning 530200,China;Guangxi University of Chinese Medicine,Guangxi Nanning 530200,China)
出处
《中医药临床杂志》
2020年第3期465-470,共6页
Clinical Journal of Traditional Chinese Medicine
基金
广西中医药大学校级科研项目(面上项目)(NO.2016MS009)
国家中医药管理局重点学科。
关键词
复方玄驹胶囊
不孕症
多囊卵巢综合征
META分析
Compound Xuanju capsule
Infertility
Polycystic ovarian syndrome(PCOS)
Meta-analysis
