摘要
目的探讨高危型HPV(HR-HPV)检测与宫颈上皮病变的关系及cobas 4800 HPV检测的应用价值。方法选取东阳市人民医院2389例HR-HPV阳性患者作为研究对象,分析HR-HPV与薄层液基细胞筛查(TCT)、宫颈活检结果之间的关系。另外选取124例宫颈活检诊断为高级别上皮内瘤变(CINⅡ-Ⅲ)和鳞状细胞癌(SCC)的患者,回顾其HR-HPV和TCT结果,分析单独HR-HPV检测、单独TCT检测以及联合筛查的预测价值。结果2389例HR-HPV阳性者中,HPV16型阳性者较其他2组感染者宫颈TCT阳性及活检结果为CINⅡ-Ⅲ和SCC的比例高,分别为24.5%(114/466)和29.7%(60/202),不同分型间差异有统计学意义(χ^2=48.105、10.195,P<0.01)。单独TCT、单独HR-HPV及两者联合筛查的灵敏度分别为80.6%、95.2%和99.2%。结论HPV16型阳性患者出现TCT及病理异常的风险最高;HR-HPV和TCT联合筛查可显著提高CINⅡ-Ⅲ和宫颈癌的检出率。cobas 4800 HPV检测能够单独识别HPV16和18型,具有临床应用价值。
Objective To evaluate the predictive and clinical value of cobas 4800 HPV detection technology in cervical intraepithelial neoplasia(CIN).Methods From January 2015 to January 2017,a total of 2389 women with high-risk HPV(HR-HPV)infection in Dongyang People’s Hospital were enrolled.The relationship among HR-HPV,thin-cytologic test(TCT)and cervical biopsy were analyzed.In addition,124 women who were diagnosed as CINⅡ-Ⅲand squamous cell carcinoma(SCC)by cervical biopsy were chosen to take HR-HPV and TCT test.The predictive values of HR-HPV test,TCT test and co-testing were evaluated.Results Among 2389 HR-HPV positive cases,the proportions of positive TCT test and CINⅡ-Ⅲ/SCC in patients with HPV16 infection were 24.5%(114/466)and 29.7%(60/202),which were significantly higher than those in other two genotype groups.The differences had statistically significance(χ^2=48.105、10.195,P<0.01).The sensitivities of TCT,HR-HPV and co-testing were 80.6%,95.2%and 99.2%,respectively.Conclusions Patients with HPV16 infection have the highest risk of abnormal TCT and pathological results.Combined screening of HR-HPV and TCT can significantly increase the detection rate of CINⅡ-Ⅲand SCC.cobas 4800 HPV test has clinical value in the diagnosis of HPV16 and 18.
作者
王倩
曾悦
王超群
黄必飞
赵永明
邵俊康
徐婷婷
Wang Qian;Zeng Yue;Wang Chaoqun;Huang Bifei;Zhao Yongming;Shao Junkang;Xu Tingting(Department of Pathology,Dongyang People’s Hospital,Jinhua 322100,Zhejiang,China;Department of Surgical Oncology,Dongyang People’s Hospital,Jinhua 322100,Zhejiang,China)
出处
《国际流行病学传染病学杂志》
CAS
2020年第2期146-148,共3页
International Journal of Epidemiology and Infectious Disease
