摘要
目的对于牙科畏惧症患儿拒绝口服药物,鼻部给药是否有优势有待进一步研究。文中旨在比较咪达唑仑的口服剂型和鼻内喷雾剂型影响牙科畏惧症患儿生理行为的差异,评估2种剂型给药方法的有效性。方法选择2018年1月至2019年5月内蒙古科技大学包头医学院第一附属医院口腔科就诊的112例患儿。按照完全随机数字表法将患儿随机分成2组:口服组(口服咪达唑仑)、鼻用组(用鼻内喷雾器将咪达唑仑药物喷入鼻中),每组56例。分别记录给予咪达唑仑、局麻0 min,治疗开始5 min、10 min、15 min、20 min、25 min时患儿的睡眠状况、哭闹状况、运动状况及整体行为评分。比较2组Ramsay量表评分及行为评分。结果口服组患儿睡眠评分[(2.01±0.11)分]与鼻用组[(1.98±0.24)分]比较差异无统计学意义(P>0.05)。鼻用组患儿治疗开始5 min时哭闹评分[(2.0±0.3)分]、运动评分[(2.1±0.1)分]、整体情况评分[(2.0±0.5)分]明显高于口服组[(1.3±0.1)分、(1.3±0.3)分、(1.4±0.2)分],差异有统计学意义(P<0.05);局麻0 min上述评分亦明显高于口服组(P<0.05)。2组患儿Ramsay镇静结果比较差异无统计学意义(P>0.05)。结论口服咪达唑仑和鼻部用药镇静效果相似,可有效缓解儿童焦虑,但口服咪达唑仑的患儿镇静起效更快。
Objective For children with dental fear who refuse to take oral medicine,the advantage of nasal administration remains undetermined.The purpose of the study was to compare the effectiveness of oral and intranasal midazolam in children with dental fear by evaluating their physiological and behavioral responses.Methods From January 2018 to May 2019,112 children were selected from the Department of Stomatology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of science and technology.Children were randomly divided into two groups:the oral group(oral midazolam)and the nasal group(nasal spray was used to spray midazolam into the nose),with 56 cases in each group.The sleep status,crying status,movement status and behavior scores were recorded at the beginning of administration,binding plate,local anesthesia,5min,10min,15min,20min and 25min respectively.The scores of Ramsay scale and behavior were compared between the two groups.Results There was no significant difference in sleep score between oral group(2.01±0.11)and nasal group(1.98±0.24)(P>0.05).The crying score[(2.0±0.3)],movement score[(2.1±0.1)],and behavior score[(2.0±0.5)]in the nasal group were significantly higher than those in the oral group[(1.3±0.1),(1.3±0.3),(1.4±0.2)],the difference was statistically significant(P<0.05);the above scores were also significantly higher at the beginning of local anesthesia(P<0.05).There was no significant difference in Ramsay Sedation between the two groups(P>0.05).Conclusion Oral midazolam and intranasal midazolam have similar sedative effects for relieving children′s anxiety.However,the sedation effect was faster of oral midazolam,which can provide guidance for children in clinical oral medicine.
作者
赵越
常秋芳
叶阳
高静
梁宏雁
鲁纯
ZHAO Yue;CHANG Qiu-fang;YE Yang;GAO Jing;LIANG Hong-yan;LU Chun(Department of Stomatology,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,Inner Mongolia,China;Tooth Fairy Dental Clinic,Jian′ye District,Nanjing 210019,Jiangsu,China)
出处
《医学研究生学报》
CAS
北大核心
2020年第5期504-508,共5页
Journal of Medical Postgraduates
基金
包头医学院科学研究基金(BYJJ-YF201734)。
关键词
咪达唑仑
牙科畏惧症
生理行为
口服
鼻内喷雾
midazolam
dental fear
physiology and behavior
oraldrugs
nasal groups
