摘要
目的:探讨咳露口服液联合酮替芬治疗咳嗽变异性哮喘的疗效及对免疫功能、炎症因子水平的影响。方法:选取2016年3月至2018年10月张家港市中医医院收治的咳嗽变异性哮喘患者150例,根据随机数字表法将患者分为对照组(n=75)和研究组(n=75)。对照组患者给予酮替芬治疗,研究组患者在对照组的基础上联合咳露口服液治疗。比较两组患者临床疗效、免疫功能、炎症因子[白细胞介素4(IL-4)、γ干扰素(IFN-γ)]水平、生活质量及不良反应发生情况的差异。结果:治疗2个月后,研究组患者的总有效率为72.00%(54/75),明显高于对照组的56.00%(42/75),差异有统计学意义(P<0.05)。治疗2个月后,两组患者CD4+、CD4+/CD8+水平较治疗前明显升高,且研究组患者明显高于对照组;两组患者CD8+水平较治疗前明显降低,且研究组患者明显低于对照组,上述差异均有统计学意义(P<0.05)。治疗2个月后,两组患者IL-4水平较治疗前明显降低,且研究组患者明显低于对照组;两组患者IFN-γ水平较治疗前明显升高,且研究组患者明显高于对照组,上述差异均有统计学意义(P<0.05)。治疗2个月后,两组患者日常生活活动评分均较治疗前明显升高,且研究组患者明显高于对照组,差异均有统计学意义(P<0.05)。对照组、研究组患者的不良反应发生率分别为16.00%(12/75)、18.67%(14/75),差异无统计学意义(P=0.666)。结论:咳露口服液联合酮替芬治疗咳嗽变异性哮喘的疗效显著,可有效改善机体免疫功能、炎症因子水平,且不增加不良反应发生概率,临床应用价值较高。
OBJECTIVE:To probe into the efficacy of Kelu oral liquid combined with ketotifen in the treatment of cough variant asthma and its effects on immune function and inflammatory factors.METHODS:Totally 150 patients with cough variant asthma admitted into Zhangjiagang Traditional Chinese Medicine Hospital from Mar.2016 to Oct.2018 were extracted to be divided into the control group and the study group via the random number table,with 75 cases in each group.The control group was given ketotifen,while the study group additionally received Kelu oral liquid bases on the control group.The clinical efficacy,immune function,inflammatory factors[interleukin 4(IL-4),γ-interferon(IFN-γ)]levels,life quality,and incidence of adverse drug reactions of two groups were compared.RESULTS:After treatment of 2 months,the total effective rate of the study group was 72.00%(54/75),significantly higher than 56.00%(42/75)in the control group,the difference was statistically significant(P<0.05).After treatment of 2 months,the levels of CD4+,CD4+/CD8+in two groups were significantly higher than those before treatment,and the study group was significantly higher than that of the control group;the levels of CD8+were significantly lower than those before treatment,and the study group was significantly lower than the control group,the above differences were statistically significant(P<0.05).After treatment of 2 months,the levels of IL-4 in two groups were significantly lower than those before treatment,and the study group was significantly lower than the control group;the levels of IFN-γin two groups were significantly higher than those before treatment,and the study group was significantly higher than the control group,with statistically significant differences(P<0.05).After treatment of 2 months,the activity of daily living scores in two groups were significantly higher than those before treatment,and the study group was significantly higher than the control group,with statistically significant differences(P<0.05).The incidence of adverse dru
作者
吴喜锋
冯高华
WU Xifeng;FENG Gaohua(Dept. of Respiratory and Critical Care Medicine, Zhangjiagang Traditional Chinese Medicine Hospital, Jiangsu Zhangjiagang 215600, China)
出处
《中国医院用药评价与分析》
2020年第4期418-420,424,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
江苏省中医药局科技项目(No.YB2015106)。
