摘要
目的:探索氧化应激标志物8-氧化鸟苷(8-oxo-Gsn)与社区老年人躯体功能的相关性。方法:选择社区年龄≥75岁的老年人210例,采用简易躯体功能评定(SPPB)方法,将入组老年人分为SPPB较好组(10~12分)、一般组(7~9分)、较差组(0~6分)。对所有入组老年人进行老年综合评估,同时检测尿8-oxo-Gsn、血超敏C反应蛋白(hs-CRP)和白细胞,采用Pearson相关性分析和有序Logistic回归分析尿8-oxo-Gsn与躯体功能的相关性。结果:SPPB较差组老年人的日常生活能力(ADL)评分、工具性日常生活能力(IADL)评分、握力和步速均低于其他两组(H=47.002、110.902,F=11.962、235.952,均P<0.001),SPPB较差组老年人的尿8-oxo-Gsn和血hs-CRP水平均高于其他两组(F=23.780、13.259,均P<0.001);尿8-oxo-dGsn和血白细胞水平3组老年人比较,差异均无统计学意义(均P>0.05)。尿8-oxo-Gsn与步速、握力和SPPB评分呈负相关(r=-0.559、-0.302、-0.450,均P<0.001),与5次起坐时间呈正相关(r=0.290,P<0.001);其中尿8-oxo-Gsn与步速的相关性最强。有序Logistic回归分析结果显示,调整年龄、性别、Charlson共病指数后,尿8-oxo-Gsn(OR=1.38,95%CI:1.06~1.77)和血hs-CRP(OR=1.23,95%CI:1.04~1.48)水平升高均可能加速躯体功能的下降。结果:尿8-oxo-Gsn与社区老年人的躯体功能下降有独立相关性,提示功能状态差的老年人体内氧化应激水平升高。
Objective To investigate the correlation between urinary 8-oxo-7,8-dihydroguanosine(8-oxo-Gsn)and physical function in community-dwelling elderly people.Methods A total of 210 community-dwelling elderly people aged 75 years and over were enrolled in this cross-sectional analysis.According to the scores of short physical performance battery(SPPB),subjects were divided into three groups:the high performance group(summary score 10-12),the intermediate performance group(summary score 7-9)and the low performance group(summary score 0-6).All participants received a comprehensive geriatric assessment.Urinary 8-oxo-dGsn,serum high-sensitivity C-reactive protein(hs-CRP)and white blood cell count were measured.The correlation between urinary 8-oxo-Gsn and physical function was analyzed by using Pearson correlation analysis and the ordered Logistic regression model.Results The scores of activities of daily living(ADL),instrumental activities of daily living(IADL),grip strength and gait speed were lower in the low performance group than in the other two groups(H=47.002,110.902,F=11.962,235.952,all P<0.001).Levels of urinary 8-oxo-Gsn and serum hs-CRP were higher in the low performance group than in the other two groups(F=23.780 and 13.259,both P<0.001).There was no significant difference in levels of urinary 8-oxo-dGsn or white blood cell count between the three groups(both P>0.05).Urinary 8-oxo-Gsn was negatively correlated with gait speed,grip strength and SPPB score(r=-0.559,-0.302 and-0.450,all P<0.001)and was positively correlated with the time of five-times-sit-to-stand test(r=0.290,P<0.001).Adjusting for age,gender and Charlson comorbidity index,the ordered Logistic regression analysis showed that elevated levels of urinary 8-oxo-Gsn(OR=1.38,95%CI:1.06-1.77,P<0.05)and hs-CRP(OR=1.23,95%CI:1.04-1.48,P<0.05)decreased physical function.Conclusions Urinary 8-oxo-Gsn is independently associated with the decline of physical function in community-dwelling elderly adults,suggesting that the oxidative stress level is increased
作者
姜珊
康琳
朱鸣雷
赵宝成
刘倩
刘晓红
Jiang Shan;Kang Lin;Zhu Minglei;Zhao Baocheng;Liu Qian;Liu Xiaohong(Peking Union Medical College,Chinese Academy of Medical Sciences,Peking Union Medical College Hospital,Beijing 100730,China;Department of Geriatrics,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Geriatrics,Taikang Rehabilitation Hospital,Beijing 102299,China;The Key Laboratory of Geriatrics,Beijing Institute of Geriatrics,Beijing Hospital,National Center of Gerontology,National Health Commission,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2020年第4期403-407,共5页
Chinese Journal of Geriatrics
基金
中国医学科学院医学与健康科技创新工程项目(2018-I2M-1-002)。
关键词
鸟苷
日常生活活动
握力
Guanosine
Activities of daily living
Hand strength
