摘要
目的评估精神分裂症高危人群的认知功能与焦虑、抑郁及精神病性症状,为该人群的早期干预提供科学依据.方法收集来源于中国医科大学附属第一医院精神医学科和沈阳市精神卫生中心就诊的门诊和住院的精神分裂症患者健康子女109人作为精神分裂症遗传高危组,通过广告招募的与精神分裂症患者健康子女年龄、性别、受教育年限相匹配的健康人群,共109人作为健康对照组.两组分别完成威斯康星卡片测试(WCST)、认知成套测试(MCCB)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD-17)和简明精神症状量表(BPRS)测试.对两组被试者的一般人口学资料、认知状况及临床特征进行统计分析处理.结果(1)精神分裂症高危组在执行功能WCST卡片测试中的总正确数(Z=-4.54,P<0.01)、正确分类数(Z=-3.78,P<0.01)、总错误数(Z=-4.49,P<0.01)、持续错误数(Z=-3.91,P<0.01)及非持续错误数(Z=-3.38,P<0.01)与健康对照组比较,差异有统计学意义;(2)精神分裂症高危组在MCCB总分(t=11.58,P<0.01)、符号编码(t=11.25,P<0.01)、视觉空间记忆(t=4.59,P=0.04)、持续操作测验(t=6.18,P=0.02)显著低于健康对照组;(3)精神分裂症高危组在HAMA总分(t=2.54,P=0.01)、HAMD-17总分(t=3.03,P<0.01)和抑郁量表中的躯体性焦虑因子(t=2.70,P<0.01)、核心抑郁因子(t=3.04,P<0.01)评分显著高于健康对照组;(4)精神分裂症高危组在BPRS总分(t=3.14,P<0.01)、焦虑和抑郁因子分(t=2.90,P<0.01)亦显著高于健康对照组.结论精神分裂症高危人群不仅存在认知功能损害,而且焦虑、抑郁以及精神病性症状高于健康人群.
Objective To evaluate the cognitive function and anxiety,depression and mental symptoms of people at high risk of schizophrenia,and provide scientific basis for early intervention of this population.Methods A total of 109 healthy children of schizophrenia outpatients and inpatients from the First Affiliated Hospital of China Medical University and Shenyang Mental Health Center were selected as the genetic high-risk group(HR)of schizophrenia.A healthy control group(HC)of 109 healthy children matched with age,gender,and years of education were recruited by advertising.The two groups completed the Wisconsin Card Sorting Test(WCST),MATRICS Consensus Cognitive Battery(MCCB),Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD-17),and Brief Psychiatric Rating Scale(BPRS).The general demographic data,cognitive status,and clinical characteristics of the two groups of subjects were analyzed.Results(1)The total number of correct(Z=-4.54,P<0.01),correct classification(Z=-3.78,P<0.01),total number of errors(Z=-4.49,P<0.01),the number of persistent errors(Z=-3.91,P<0.01)and the number of non-persistent errors(Z=-3.38,P<0.01)were significantly different for the HR group from the HC group,(2)The HR group's total score of MCCB(t=11.58,P<0.01),symbol coding(t=11.25,P<0.01),visual spatial memory(t=4.59,P=0.04),and continuous operation test(t=6.18,P=0.02)were significantly lower than those of the HC group;the total HAMA score(t=2.54,P<0.01).(3)The total HAMD-17 score(t=3.03,P<0.01),the somatic anxiety factors(t=2.70,P<0.01)and core depression factors(t=3.04,P<0.01)in the depression scale in the HR group were significantly higher than those in the HC group.(4)The total score of BPRS(t=3.14,P<0.01),anxiety and depression factor scores(t=2.90,P<0.01)in the HR group were significantly higher than the HC group.Conclusions Cognitive functions are impaired in individuals at high risk of schizophrenia and anxiety,depression,and mental symptoms are higher than the healthy population.
作者
冷海霞
朱玥
王菲
汤艳清
Leng Haixia;Zhu Yue;Wang Fei;Tang Yanqing(Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;First Affiliated Hospital of China Medical University,Shenyang 110001,China)
出处
《神经疾病与精神卫生》
2020年第1期21-26,共6页
Journal of Neuroscience and Mental Health
基金
国家自然科学基金面上项目(81571311)。
关键词
精神分裂症
高危人群
认知功能
抑郁
焦虑
Schizophrenia
High risk population
Cognitive function
Depression
Anxiety
