摘要
每年流感在全球范围内引起约50万的死亡病例和超过300万的重症病例,流感疫苗是预防控制流感暴发和流行的最经济、有效的方法。将佐剂应用至流感疫苗中,不但能有效降低抗原用量,减轻经济负担,而且良好的佐剂能显著提高机体体液免疫应答及细胞免疫应答。因此研究和开发流感疫苗佐剂具有重要意义,国内外的研究者均进行了深入和广泛的研究。本文对流感疫苗佐剂的应用现状及研究进展进行综述,旨在为开发新型佐剂提供参考。
Typically,there are between three and five million cases of severe illness and around 500 000 deaths worldwide,caused by influenza virus. Influenza vaccines are the most economical and effective way to prevent and control influenza outbreaks and epidemics. Adjuvant may effectively reduce the amount of antigen and the patients’ economic burden,while significantly enhance the humoral and cellular immune response. The development of adjuvant for influenza vaccine is of important significance. Researchers at home and abroad have conducted in-depth and extensive researches on these issues. The application status and research progress of adjuvant for influenza vaccine are reviewed in this paper so as to provide a reference for the development of novel adjuvant.
作者
李宗霖(综述)
廖国阳(审校)
LI Zong-lin;LIAO Guo-yang(Institute of Medical Biologr,Chinese Academy of Medical Science and Peking Union Medical College,Kunming 650018,Yunnan Province,China)
出处
《中国生物制品学杂志》
CAS
CSCD
2020年第4期465-469,共5页
Chinese Journal of Biologicals
基金
国家科技部重大专项(2013ZX10004003-003-002)
国际合作项目(2011DFR30420)
中国医学科学院医学科技创新团队(2016-I2M-3-026)
云南省创新团队(2015HC027)。
关键词
流感疫苗
佐剂
免疫应答
Influenza vaccine
Adjuvant
Immune response
