摘要
目的探讨检测多肽-N乙酰氨基半乳糖转移酶10(ppGalNAc-T10)单细胞技术与应用蛋白在肺癌、乳腺癌和结肠癌中的表达。方法采用免疫组织化学检测ppGalNAc-T10在110例肺癌组织、100例乳腺癌组织和110例结肠癌组织中的表达;不同的肿瘤均有10例相对应的正常组织作为对照。结果同正常肺组织相比较,ppGalNAc-T10在肺癌组织中表达较低;且ppGalNAc-T10的表达与肿瘤侵袭深度相关(P<0.01)。PpGalNAc-T10蛋白在乳腺癌和结肠癌及其相对应的正常组织的表达差异无显著性。结论PpGalNAc-T10在肺癌中,有可能成为的1个有效标记蛋白。
Objective The purpose of this study is to investigate the expression of the polypeptide Nacetylgalactosaminyltransferase-10(ppGalNAc-T10)protein in lung and breast and colon cancer.Methods Immunohistochemistry was used to analyse ppGalNAc-T10 expressions in 110 lung cancer tissues,100 breast cancer tissues and 110 colon cancer tissues.Meanwhile,different cancer has 10 cases of normal tissues as control.Results The expression of ppGalNAc-T10 in normal lung tissue was higher compared with that in lung cancer organizations,and ppGalNAc-T10 positive expression was found to be significantly associated with invasion depth of tumor(P<0.01).Pp Gal NAc-T10 protein expression in breast and colon cancer was no significantly difference than that in non-tumor breast and colon tissue.Conclusion Pp Gal NAc-T10 expression is a useful marker in lung cancer.
作者
蔡翠霞
高媛
刘玥
王涵多
CAI Cui-xia;GAO Yuan;LIU Yue;WANG Han-duo(School of Basic Medical Science,Guangdong Provincial Key Laboratory of Single Cell Technology and Application,Southern Medical University,Guangzhou 510515,China)
出处
《解剖学报》
CAS
CSCD
北大核心
2020年第2期206-210,共5页
Acta Anatomica Sinica
基金
Natural Science Foundation of Guangdong Province(2015A030310468)。
关键词
肺癌
乳腺癌
结肠癌
多肽-N乙酰氨基半乳糖转移酶10
人
Lung cancer
Breast cancer
Colon cancer
Polypeptide N-acetylgalactosaminyltransferase-10
Human
