摘要
目的探讨丙戊酸钠和卡马西平治疗癫痫患者的效果对比。方法方便选取2017年3月-2018年10月于该院治疗的癫痫患者60例,运用随机数字表法分为治疗组(29例),对照组(31例)。治疗组予以丙戊酸钠进行治疗,对照组予以卡马西平进行治疗,两组均治疗6个月。观察并记录两组患者治疗前后甲状腺功能变化、氧化应激指标;并采用MMSE量表评估两组认知功能。结果治疗后对照组T3、T4、FT3、FT4较治疗前降低(P<0.05),且低于治疗组(P<0.05);治疗后治疗组SOD、MPO指标分别为(51.86±8.22)U/mL、(422.56±110.71)U/L较治疗前降低,MDA(7.44±1.32)nmol/mL较治疗前上升,上述指标改善程度优于对照组,两组比较差异有统计学意义(t=9.624、11.368、5.427,P<0.05);治疗3、6个月后两组MMSE评分分别为治疗组[(26.92±3.96)分、(30.79±3.32)分]vs[(24.48±3.88)分、(27.12±3.08)分]均较治疗前显著升高(t=5.011、12.365,P<0.05),且治疗组各个时间点均高于对照组(P<0.05)。结论丙戊酸钠对机体甲状腺功能无显著影响,可改善机体氧化应激反应及患者认知功能,疗效优于卡马西平。
Objective To compare the effects of sodium valproate and carbamazepine in the treatment of patients with epilepsy.Methods Sixty patients with epilepsy who were treated in our hospital from March 2017 to October 2018 were randomly divided into the treatment group(29 cases)and the control group(31 cases).The treatment group was treated with sodium valproate,and the control group was treated with carbamazepine.Both groups were treated for 6 months.Observe and record the changes of thyroid function and oxidative stress in the two groups before and after treatment;and use the MMSE scale to evaluate the cognitive function of the two groups.Results After treatment,the T3,T4,FT3 and FT4 of the control group were lower than those before treatment(P<0.05),and lower than the treatment group(P<0.05).The SOD and MPO indexes of the treatment group were(51.86±8.22)U/mL after treatment.(422.56±110.71)U/L decreased compared with before treatment,MDA(7.44±1.32)nmol/mL increased compared with before treatment,the above indicators improved better than the control group,the difference between the two groups was statistically significant(t=9.624,11.368,5.427,P<0.05);after 3 and 6 months of treatment,the MMSE scores of the two groups were respectively in the treatment group[(26.92±3.96)points,(30.79±3.32)points]vs[(24.48±3.88)points,(27.12±3.08)points] were significantly higher than before treatment(t=5.011,12.365,P<0.05),and the treatment group was higher than the control group at each time point(P<0.05).Conclusion Sodium valproate has no significant effect on thyroid function,which can improve oxidative stress and cognitive function of patients,and its curative effect is better than carbamazepine.
作者
龙旭
保云梅
LONG Xu;BAO Yun-mei(Department of Neurology,First People's Hospital of Honghe Prefecture,Honghe,Yunnan Province,661199 China;Department of Critical Care Medicine,First People's Hospital of Honghe Prefecture,Honghe,Yunnan Province,661199 China)
出处
《中外医疗》
2020年第4期107-109,共3页
China & Foreign Medical Treatment
关键词
癫痫
丙戊酸钠
卡马西平
认知功能
Epilepsy
Sodium valproate
Carbamazepine
Cognitive function
