摘要
目的了解宁夏回族自治区男男性行为人群(MSM)艾滋病抗病毒治疗特征和发现即治疗策略在此人群中实施的影响因素。方法收集艾滋病抗病毒治疗数据库中宁夏2010-2017年艾滋病抗病毒治疗的MSM患者基本信息,应用Excel 2016建立数据库,SPSS 23.0进行数据分析。结果宁夏2010-2017年,580例研究对象的年龄、婚姻状态、住址各组构成比均保持稳定。治疗开始时79.7%为WHO临床分期Ⅰ期,92.9%无任何症状体征,基线CD4^+T淋巴细胞(CD4细胞)计数M(P25~P75)为340(232~482)个/μl,感染艾滋病病毒(HIV)确诊阳性时间与开始治疗时间间隔M(P25~P75)为1(0~13)个月。从2010-2017年,治疗开始时无任何症状体征、WHO临床分期Ⅰ期、CD4细胞计数≥500/μl、确诊后1个月内开始抗病毒治疗(发现即治疗)的MSM人群构成比呈上升趋势。Logistic回归多因素分析显示,已婚或同居、居住地吴忠市是发现即治疗策略的危险因素。结论宁夏MSM人群开始艾滋病抗病毒治疗时机有所提前,年龄、婚姻状态、住址、CD4细胞计数与发现即治疗有关,建议应进一步加强病例管理工作,贯彻好发现即治疗的策略。
Objective To understand the characteristics of antiviral treatment of AIDS in MSM in Ningxia and the factors influencing the implementation of discovery and treatment strategy.Methods The information of MSM patients received HIV/AIDS antiviral treatment in Ningxia were collected from National HIV/AIDS Information System from 2010 to 2017,and the database was established by Excel 2016,Data were analyzed by SPSS 23.0.Results Of the 580 cases,constituent ratio of age,marital status,and residential address were all stable.At the beginning of treatment,79.7% of them were in clinical phase Ⅰ,92.9% of them had no any symptoms,the average baseline CD4+T lymphocyte count was 340(232~482),the median of the interval between HIV confirmation and ART initiation was one month.Proportion of MSM without any symptoms of clinical phase Ⅰ,CD4 cell count≥500/μl,and antiviral treatment within one month after diagnosis showed an increased trend from 2010 to 2017.Multivariate logistic regression analysis showed that married or cohabitation,living in Wuzhong were the associated factors of early treatment.Conclusion In Ningxia,the time of HIV antiviral treatment for MSM is earlier than before,Age,marital status,address,CD4+T lymphocyte count were the factors associated with early treatment.It is suggested that case management should be further strengthened to implement the strategy of discovery as treatment.
作者
沈湜
吴忠兰
赵立华
樊佩苗
杨东智
马学旻
吴惠忠
SHEN Shi;WU Zhonglan;ZHAO Lihua;FAN Peimiao;YANG Dongzhi;MA Xuemin;WU Huizhong(Ningxia Medical University,Yinchuan 750004,China;Ningxia Hui Autonomous Region Center for Disease Prevention and Control,Yinchuan 750004,China)
出处
《宁夏医学杂志》
CAS
2020年第4期314-318,共5页
Ningxia Medical Journal
基金
宁夏重点研发项目(2018BEG03065)
宁夏青年拔尖人才项目(RQ0126)
宁夏自然科学基金资助项目(2018AAC03212)。
