摘要
目的探讨红细胞体积分布宽度(ROW)、氨基末端脑钠肽前体(NT-proBNP)、可溶性ST2(sST2)与急性失代偿期射血分数保留心力衰竭(HFpEF)患者预后的关系。方法选取我院确诊的100例HFpEF患者,按照患者随访1年内是否有心力衰竭相关不良事件发生分为预后不良组40例、预后良好组60例;对比两组患者的RDW、NT-proBNP、sST2测定值及一般资料,采用Logistic回归法分析影响HFpEF患者预后的危险因素。结果预后不良组与预后良好组患者的年龄、性别、BMI、吸烟、糖尿病、高血脂、心率、用药治疗情况差异无统计学意义(P>0.05);预后不良组和预后良好组患者的合并高血压、NYHA分级比较,差异具有统计学意义(P<O.O5);预后不良组患者的RDW、NT-proBNP测定值高于预后良好组患者,差异具有统计学意义(P<0.05);预后不良组患者的sST2测定结果低于预后,良好组患者,差异具有统计学意义(P<0.05);Logistic回归分析结果显示:HFpEF患者RDW升高、NT-proBNP升高、合并高血压、NYHA分级Ⅳ级会增大不良预后的风险(P<0.05)。结论RDW、NT-proBNP升高与HFpEF患者不良预后有关,sST2水平变化与HFpEF患者不良预后关系不明显。
Objective To investigate the relationship between red blood cell volume distribution width(RDW),amino terminal pro-brain natriuretic peptide(NT-proBNP),soluble ST2(sST2)and prognosis of acute decompensated ejection fraction in patients with heart failure(HFpEF).Methods One hundred patients with HFpEF diagnosed in our hospital were enrolled.According to whether there were any adverse events related to heart failure within 1 year after follow-up,40 patients with poor prognosis and 60 patients with good prognosis were included.RDW,NT-proBNP and sST2 were compared between the two groups.Value and general data were used to analyze risk factors affecting the prognosis of patients with HFpEF by logistic regression.Results There were no significant differences in age,gender,BMI,smoking,diabetes,hyperlipidemia,heart rate,and medication between patients with poor prognosis and those with good prognosis(P>0.05).There was significant difference between the poor prognosis and the good prognosis(P<0.05).The RDW and NT-proBNP values in patients with poor prognosis were higher than those in good prognosis group(P<0.05).The sST2 test result in patients with poor prognosis was lower than that with good prognosis(P>0.05).Logistic regression analysis result showed:RDW elevation,NT-proBNP elevation,hypertension,NYHA grade Ⅳ increased the risk of poor prognosis(P<0.05).Conclusion Elevated RDW and NT-proBNP were associated with poor prognosis in patients with HFpEF,and sST2 levels were not significantly associated with poor prognosis in patients with HFpEF.
作者
宋银雪
许静
梁欢
高烨
SONG Yinxue;XU Jing;LIANG Huan;Gao Ye(Emergency Department,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China)
出处
《中国急救复苏与灾害医学杂志》
2020年第4期470-473,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
国家自然科学基金青年科学基金项目(编号:81601674)。
关键词
红细胞体积分布宽度
氨基末端脑钠肽前体
可溶性ST2
急性失代偿期
射血分数保留
心力衰竭
预后
Red blood cell volume distribution width
Amino terminal brain natriuretic peptide precursor
Soluble ST2
Acute decompensation
Ejection fraction retention
heart failure
Prognosis
