摘要
抑郁症发病机制复杂,多种转录因子、信号通路等参与其发生、发展过程。中药的多成分、多靶点作用在抑郁症的防治中具有独特优势。本文根据国内外相关文献,综述了中药及其活性成分对转录因子(CREB、NF-κB、Nrf2)、分子信号通路(BDNF-TrkB、MAPK、GSK-3β、TLR-4-NLRP3-IL-1β)等靶点干预的药理作用及中药复方防治抑郁症的临床应用。
The pathological mechanism for depression is complicated due to the involvement of types of transcriptional factors and signaling pathways in the occurrence and development of depression.Traditional Chinese medicine(TCM)characterized with multi-components and multi-targets exert unique advantage in the prevention and treatment of depression.This review summarized the pharmacological action of TCM and active components on transcriptional factors(CREB,NF-κB,Nrf2)and signaling pathways(BDNF-TrkB,MAPK,GSK-3β,TLR-4-NLRP3-IL-1β)as well as elucidated the clinical application of TCM formula in the prevention and treatment for depression based on relevant literatures from home and abroad.
作者
冯睿
张佳莉
赫明超
李钺
张岩
FENG Rui;ZHANG Jiali;HE Mingchao;LI Yue;ZHANG Yan(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Key Laboratory(Theory and Therapy of Muscles and Bones)of Ministry of Education,Shanghai 200032,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2020年第4期467-474,共8页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
科技部重大新药创制资助(2019ZX09201004-003-032)
上海市市级医疗卫生优秀学科带头人培养计划资助(2018BR03)
上海市优秀学术带头人计划资助(19XD1423800)。
关键词
中药
抑郁症
转录因子
信号通路
作用靶点
Traditional Chinese medicine
depression
transcriptional factor
signaling pathway
action target
