摘要
微RNA(miRNA)是一类长度为21~25个核苷酸的非编码小分子RNA。其通过靶向降解信使RNA(mRNA)或抑制mRNA被翻译为蛋白质参与个体发育及细胞增殖、分化、凋亡等一系列重要生物学进程,与人类多种疾病的发生、发展密切相关。miRNA作为潜在的促癌基因或抑癌基因在结直肠癌、胃癌、乳腺癌、肝癌、肺癌等的发生、发展中有调控作用,可作为某些癌症的潜在治疗靶点。
MicroRNA(miRNA) is a type of non-coding small molecule RNA with a length of 21-25 nucleotides. Through targeting degradation of messenger RNA(mRNA) or inhibition of mRNA translation into proteins, miRNA is involved in a series of important biological processes such as individual development, cell proliferation, differentiation and apoptosis, which are closely related to the occurrence and development of various human diseases. As a potential oncogene or tumor suppressor gene, miRNA plays a regulatory role in the occurrence and development of colorectal cancer, gastric cancer, breast cancer, liver cancer, lung cancer, etc. And miRNA can be used as a potential therapeutic target for some tumor.
作者
耿帅
郭宏举
史宁
汤晴
常李荣
GENG Shuai;GUO Hong-ju;SHI Ning;TANG Qing;CHANG Li-rong(Department of Pharmacy,Strategic Support Forces Medical Center,BEIJING 100101,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2020年第4期193-197,共5页
Chinese Journal of New Drugs and Clinical Remedies
基金
战略支援部队特色医学中心医药卫生军事医学研究课题(19ZX17)。
