摘要
近年来,循环游离DNA(cell free DNA,cfDNA)的液体活检已成为诊断癌症的辅助手段。由于该手段具有无创、快速等优点,它在头颈鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)诊断、治疗后监测及耐药性检测等方面的作用日益突出。本文对cfDNA的生物特性、提取与检测、在HNSCC中的临床应用,以及在HNSCC中发生、发展的作用进行综述,以期为相关科学研究和临床治疗提供思路。
In recent years,cfDNA(cell free DNA,cfDNA)liquid biopsy is rapidly becoming an adjunct for standard tumor biopsy.As a noninvasive and rapid tool,it has been used in diagnostics,post treatment surveillance and assessment of drug resistance in head and neck squamous cell carcinoma(HNSCC).This paper summarizes the characteristics,extraction and detection,clinical application and function of cfDNA in HNSCC,which provides a theoretical basis for clinical treatment and scientific research of HNSCC.
作者
郑适泽
乔春燕
孟琳
任飞龙
李玮柏
任春霞
陈雨蒙
孙宏晨
ZHENG Shize;QIAO Chunyan;MENG Lin;REN Feilong;LI Weibo;REN Chunxia;CHEN Yumeng;SUN Hongchen(Key Laboratory of Tooth Development and Jaw Remodeling and Regeneration;Department of Pathology,School and Hospital of Stomatology,Jilin University;School and Hospital of Stomatology,Jilin University;Department of Periodontology,Schooland Hospital of Stomatology,Jilin University,Changchun 130021,Jilin Province,China)
出处
《口腔颌面外科杂志》
CAS
2020年第2期110-116,共7页
Journal of Oral and Maxillofacial Surgery
基金
国家自然科学基金重点国际(地区)合作研究项目(81920108012)
吉林省科技厅优秀青年人才基金项目(20180520058H)。
关键词
循环游离DNA
头颈鳞状细胞癌
肿瘤异质性
肿瘤免疫
液体活检
cell free DNA
head and neck squamous cell carcinoma(HNSCC)
tumor heterogeneity
tumor immunity
liquid biopsy
