摘要
新型冠状病毒肺炎是一种由新型冠状病毒引发的急性传染病,已在全球呈现多点暴发趋势。近期的多项研究显示新型冠状病毒的S蛋白RBD区域可以和血管紧张素转化酶Ⅱ结合进入细胞。因此,血管紧张素转化酶Ⅱ与病毒感染细胞密切相关,可能是新型冠状病毒肺炎潜在的治疗靶点,深入研究血管紧张素转化酶Ⅱ与新型冠状病毒之间的关系将有助于把控人群遗传易感性及药物研发,推动疾控、临床和科研人员更快地制定出相关防控、诊疗方案。本研究综述新型冠状病毒及细胞表面受体血管紧张素转化酶Ⅱ目前的研究进展。
Corona Virus Disease 2019(COVID-19)is an acute infectious disease,with a multipoint tendency,which has been caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).There have been several reports showing that SARS-CoV-2 was revealed as binding to angiotensin converting enzymeⅡ(ACE2)by spike protein and entering the cell.ACE2 is a key point to virus-infected cells apparently.Therefore it will be a potential therapeutic target for SARS-CoV-2.It is necessary to explore the relationship between ACE2 and SARS-CoV-2,which is of great significance in controlling the genetic susceptibility of the population and subsequent drug research and development.It will also be helpful in disease control and clinical methods,also facilitating researchers in establishing relevant ways of prevention and control and deciding upon appropriate diagnosis and therapeutic plans faster.The advancement of studies on SARS-CoV-2 and ACE2 was reviewed in this paper.
作者
马青龙
张立婷
杨文柯
伊琳
同重湘
李书艳
谢小冬
Ma Qing-long;Zhang Li-ting;YangWen-ke;Yi Lin;Tong Chong-xiang;Li Shu-yan;Xie Xiao-dong(Institute of Genetics,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China;Department of Infectious Disease,The First Hospital of Lanzhou University,Lanzhou 730000,China;School of Integrated Traditional Chinese andWestern Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Clinical Laboratory,Lanzhou Pulmonary Hospital,Lanzhou 730046,China;Institute of Life Analytical Chemistry and Molecular and Atomic Engineering,College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China)
出处
《兰州大学学报（医学版）》
CAS
2020年第2期70-75,共6页
Journal of Lanzhou University（Medical Sciences）
基金
甘肃省重点研发计划项目《基于高原环境下易感人群遗传特征的抗新型冠状病毒诊疗模式的建立》
兰州大学中央高校基本科研业务费专项资金项目(lzujbky-2020-sp11)。
关键词
新型冠状病毒
新型冠状病毒肺炎
血管紧张素转化酶Ⅱ
刺突蛋白
severe acute respiratory syndrome coronavirus 2
Corona Virus Disease 2019
angiotensin converting enzymeⅡ
spike protein
