摘要
目的分析重复经颅磁刺激(rTMS)联合盐酸帕罗西汀治疗产后抑郁的效果。方法选取本院2017年1月—2017年12月收治的产后抑郁患者50例作为观察对象。产后抑郁采用《美国精神疾病诊断和统计手册(第四版)》中产后抑郁的诊断标准。采用随机数字表法将其分为观察组和对照组各25例。观察组给予盐酸帕罗西汀联合rTMS真刺激治疗,对照组给予盐酸帕罗西汀联合rTMS假刺激治疗,两组的盐酸帕罗西汀用量均为20 mg/d,两组均治疗6周。比较两组治疗前、治疗后1周、2周、4周、6周时的产后抑郁症状(EPDS量表);比较两组治疗前后的孕酮(P)、雌二醇(E2)水平、治疗效果和不良反应发生情况。结果治疗2、4、6周后,观察组EPDS评分均明显低于对照组(P<0.05);治疗后,观察组P和E2水平均明显高于对照组(P<0.05);观察组治疗总有效率为96.0%,明显高于对照组的72.0%(P<0.05);观察组不良反应发生率为24.0%,与对照组的36.0%比较,差异无统计学意义(P>0.05)。结论盐酸帕罗西汀联合rTMS能够显著改善产后抑郁患者的抑郁状态,提高患者的雌激素水平,提高疗效,且未增加不良反应发生率。
Objective To analyze the effect of repetitive transcranial magnetic stimulation(rTMS)combined with Paroxetine Hydrochloride in the treatment of postpartum depression.MethodsFifty patients with postpartum depression admitted to our hospital were selected from January 2017 to December 2017.Diagnostic criteria of postpartum depression was compliance with in the American Manual of Diagnosis and Statistics of Mental Diseases(4th edition).The objects were divided into observation group and control group with 25 cases in each by random number table method.The control group was treated with Paroxetine Combined with rTMS pseudo stimulation,while the observation group was treated with Paroxetine Combined with rTMS true stimulation.The dosage of paroxetine in both groups was 20 mg/d,and both groups were treated for 6 weeks.The postpartum depressive symptoms(EPDS scale)of two groups were compared before and after treatment,1 weeks,2 weeks,4 weeks and 6 weeks after treatment and the levels of progesterone(P),estradiol(E2),treatment effect and adverse reaction were compared before and after treatment in the two groups.ResultsThe EPDS score of the observation group was significantly lower than that of the control group(P<0.05)after 2,4,6 weeks of treatment.After treatment,the level of P and E2 in the observation group was significantly higher than that of the control group(P<0.05),and the total effective rate in the observation group was 96.0%,which was significantly higher than that in the control group(72.0%)(P<0.05),and the incidence of adverse reactions in the observation group was 24.0%,There was no significant difference between the control group and the control group(36.0%)(P>0.05).ConclusionParoxetine hydrochloride combined with rTMS can significantly improve the depressive state of the patients with postpartum depression,improve the level of estrogen in the patients,improve the curative effect,and do not increase the adverse reaction.
作者
王祯
蒋天梅
李德波
苏梅红
罗春妮
WANG Zhen;JIANG Tianmei;LI Debo;SU Meihong;LUO Chunni(Department of Obstetrics and Gynecology, Guangxi Zhuang Autonomous Region Brain Hospital,Liuzhou, 545000)
出处
《中国生育健康杂志》
2020年第3期219-222,共4页
Chinese Journal of Reproductive Health
基金
国家自然科学基金(81560468)。
关键词
重复经颅磁刺激
盐酸帕罗西汀
产后抑郁
repetitive transcranial magnetic stimulation
Paroxetine Hydrochloride
postpartum depression
