摘要
目的探讨外周血淋巴细胞/单核细胞比值(LMR)与系统性红斑狼疮(SLE)疾病活动度及狼疮性肾损害程度的相关性。方法选取武汉大学人民医院2016年1月~2019年9月皮肤科及肾内科确诊的初治SLE患者102例,其中46例合并狼疮性肾炎。根据SLE疾病活动度(SLEDAI)评分,将患者分为疾病稳定组(SLEDAI评分≤9分)37例,疾病活动组(SLEDAI评分﹥9分)65例;根据24h尿蛋白总量将患者分为3组,即轻度蛋白尿组(24h尿蛋白总量<0.5g,n=56)、中度蛋白尿组(24h尿蛋白总量0.5~4.0g,n=36)、重度蛋白尿组(24h尿蛋白总量≥4.0g,n=10),分别比较以上各组的LMR值,同时利用Spearman相关分析分析LMR与SLE患者实验室指标的相关性,采用多重线性回归模型分析LMR与SLEDAI评分之间的关系。结果SLE疾病活动组LMR明显低于稳定组,差异有统计学意义(P<0.01)。重度蛋白尿组、中度蛋白尿组患者LMR均明显低于轻度蛋白尿组,差异有统计学意义(P<0.01)。Spearman相关分析结果显示,LMR分别与SLEDAI评分(r=-0.628,P=0.000)、24h尿蛋白总量(r=-0.233,P=0.001)呈负相关,与补体C3(r=0.272,P=0.006)、补体C4(r=0.270,P=0.006)、血小板计数(r=0.263,P=0.007)、血红蛋白(r=0.233,P=0.018)呈正相关。多重线性回归模型分析显示,LMR与SLEDAI评分独立相关(β=-3.589,95%CI:-5.221^-1.958,t=-4.366,P=0.001)。结论LMR与SLE疾病活动度及狼疮性肾损害密切相关,对于评估SLE疾病活动度及狼疮肾损害程度具有重要意义。
Objective To investigate the relationship between lymphocyte-monocyte ratio and disease activity of SLE and degree of lupus nephritis.Methods A total of 102 SLE patients admitted to Dermatological Department and Nephrology Department of Renmin Hospital of Wuhan University from January 2016 to September 2019 were enrolled,46 of whom were LN inpatients.According to SLEDAI score,37 cases were in inactive group(SLEDAI≤9)and 65 in active group(SLEDAI﹥9).According to 24-hour urinary total protein,patients were divided into mild proteinuria group(24-hour urinary total protein<0.5g)56 cases,moderate proteinuria group(24-hour urinary total protein 0.5-4.0g)36 cases,severe proteinuria group(24-hour urinary total protein≥4.0g)10 cases.The LMR values of the above groups were compared.Spearman′s correlation analysis was used to analyze the correlation between LMR and SLE patients′laboratory indexes.Multiple linear regression model was used to analyze the relationship between LMR and SLE disease activity.Results The LMR value of SLE patients in active group was lower than that in inactive group(P<0.01).The LMR value of SLE patients in moderate proteinuria group and severe proteinuria group were lower than that in mild proteinuria group(both P<0.01).The LMR of SLE patients was negatively correlated with SLEDAI score(r=-0.628,P=0.000)and 24-hour urinary total protein(r=-0.233,P=0.001),and positively correlated with C3 complements(r=0.272,P=0.006),C4 complements(r=0.270,P=0.006),platelet count(r=0.263,P=0.007),hemoglobin(r=0.233,P=0.018).Multiple linear regression showed that LMR was independently associated with SLE disease activity(β=-3.589,95%CI:-5.221--1.958,t=-4.366,P=0.001).Conclusion The LMR value is closely related to SLE disease activity and proteinuria,and is of great significance for the assessment of SLE disease activity and degree of lupus nephritis.
作者
刘圆圆
陈星华
丁国华
Liu Yuanyuan;Chen Xinghua;Ding Guohua(Wuhan University First Clinical College,Hubei 430060,China)
出处
《医学研究杂志》
2020年第4期52-56,86,共6页
Journal of Medical Research
基金
国家自然科学基金资助项目(81500516)。
