摘要
目的研究儿童炎症性肠病(IBD)中血小板及凝血功能指标的变化,并探究与疾病活动度之间的关系。方法选取2015-01-01-2018-06-30首都医科大学附属北京儿童医院消化科75例IBD患儿为研究对象,其中克罗恩病(CD)患儿40例,溃疡性结肠炎(UC)患儿35例,同时纳入50名健康体检儿童为对照组。回顾性收集患儿的临床资料、血小板数量(PLT)、平均血小板体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)、凝血酶原时间(PT)、纤维蛋白原(FIB)、部分凝血活酶时间(APTT),探究各指标变化及与疾病活动度的相关性。结果活动期CD和UC患儿PLT、PCT、FIB、PT均显著高于健康对照组,MPV显著低于健康对照组(P<0.05);缓解期CD患儿PLT、PCT显著高于健康对照组,缓解期UC患儿PDW显著高于健康对照组(P<0.05),且CD患儿活动期及缓解期的PLT数量、PCT均明显高于UC患儿,PDW均明显低于UC患儿。进一步对各指标与疾病活动度进行分析,结果显示CD患儿中PLT数量、MPV、PDW与疾病活动度相关(r=0.351,-0.361,-0.651,P<0.05),UC患儿中PLT数量、PDW、PCT与疾病活动度相关(r=0.529,-0.354,0.485,P<0.05)。结论儿童CD和UC患者体内血小板及凝血指标存在异常,主要表现为PLT、PCT、FIB、PT增高,MPV下降,PLT、MPV、PDW、PCT的变化与IBD疾病活动度相关。
Objective To investigate the changes in the platelet parameters and coagulation biomarkers in pediatric inflammatory bowel disease(IBD),and to determine the correlation between these biomarkers and disease activity in IBD.Methods Totally 75 children with IBD were chosen as research subjects,who were treated in Beijing Children’ s Hospital,Capital Medical University from January 1,2015 to June 30,2018,of whom 40 were with Crohn’s disease(CD) and 35 with ulcerative colitis(UC);50 healthy children were included as controls.Clinical data,platelet count(PLT),mean platelet volume(MPV),plateletcrit(PCT),platelet distribution width(PDW),prothrombin time(PT),fibrinogen(FIB),and activated partial thromboplastin time(APTT) were collected and restrospectively analyzed.The relationship between these changes and the disease activity was studied.Results A significant increase in PLT,PCT,FIB,PT and a significant decrease in MPV were noted in patients with active CD and UC compared with healthy control(P <0.05).PLT and PCT were significantly higher in patients in CD remission than in healthy controls,the PDW was significantly higher in patients in UC remission than in healthy controls(P<0.05).The children with CD had a higher platelet count and PCT and a lower PDW than children with UC.Further analysis showed that PLT number,MPV and PDW were correlated with disease activity in CD children(r=0.351,-0.361,-0.651,P<0.05),while in UC children,PLT number,PDW and PCT were correlated with disease activity(r=0.529,-0.354,0.485,P<0.05).Conclusion Children with CD and UC have an increase in PLT,PCT,PT,FIB and a decrease in MPV and PLT,MPV,PDW,PCT are associated with disease activity in patients with IBD.
作者
钟瑶瑶
官德秀
梅天璐
周锦
王国丽
于飞鸿
徐樨巍
ZHONG Yao-yao;GUAN De-xiu;MEI Tian-lu(Department of Gastroenterology,Beijing Children’s Hospital,Capital Medical University,Faculty of Digestive Diseases,Capital Medical University,National Clinical Research Center for Digestive Diseases,Beijing 100045,China)
出处
《中国实用儿科杂志》
CSCD
北大核心
2020年第4期311-314,328,共5页
Chinese Journal of Practical Pediatrics
基金
首都临床特色应用研究与成果推广项目(Z151100004015074)。
关键词
儿童
炎症性肠病
血小板
凝血功能
child
inflammatory bowel disease
platelet
coagulation
