摘要
血清素是一种吲哚衍生物,可由色氨酸经羟化、脱羧两步反应得到。在人和动物体内,血清素作为神经递质参与包括情绪调控、行为管理、睡眠周期维持等多种生理功能。相较化学合成法,微生物法生产血清素因具有低成本、低污染、可放大生产规模等优点而备受青睐。该文将从血清素生物合成途径中关键酶基因和发酵工艺控制两方面阐述近年来生物合成血清素的研究进展,为今后大规模工业化生产血清素提供可靠的科学依据。
Serotonin,known as a kind of indole derivatives,is obtained via hydroxylation and decarboxylation from tryptophan.As a neurotransmitter from humans and animals,serotonin is involved in a variety of physiological functions including emotional regulation,behavior management,sleep cycle maintenance etc.Compared to chemical synthesis,microbiological production of serotonin has 3 advantages:low cost,low pollution,and can be scaled up.In conclusion,this review provides the optimization of key enzyme genes and the control of fermentation process for large-scale industrializationof serotonin in the future.
作者
沈培杰
祁峰
黄建忠
SHEN Pei-jie;QI Feng;HUANG Jian-zhong(School of Life Science,Fujian Normal University,Fuzhou 350117,China)
出处
《药物生物技术》
CAS
2020年第1期68-72,共5页
Pharmaceutical Biotechnology
基金
国家自然科学基金项目资助(No.21406130)。
关键词
色氨酸
5-羟基色氨酸
血清素
生物合成途径
关键酶
发酵策略
Tryptophan
5-Hydroxytryptophan
Serotonin
Biosynthesis pathway
Key enzymes
Fermentation strategies
