摘要
目的观察滋肾续骨汤联合鲑鱼降钙素对老年椎体压缩性骨折术后血清骨形态发生蛋白9(BMP9)及血管内皮生长因子(VEGF)水平的影响。方法将80例老年椎体压缩性骨折术后患者按照随机数字表法分为2组。对照组39例予鲑鱼降钙素治疗;治疗组41例在对照组治疗基础上加用滋肾续骨汤治疗。2组均治疗24周后统计临床疗效,并观察2组治疗前后血清BMP9、VEGF水平及疼痛视觉模拟评分(VAS)、胸腰椎损伤分类及损伤程度评分系统(TLICS)、Oswestry功能障碍指数(ODI)评分、日本骨科协会(JOA)腰痛评分,以及椎体前缘丢失高度、伤椎Cobb角、伤椎骨密度水平及并发症发生情况。结果治疗组总有效率95.12%(39/41),对照组总有效率76.92%(30/39),治疗组临床疗效优于对照组(P<0.05)。2组治疗后血清BMP9、VEGF水平均升高(P<0.05),且治疗组高于对照组(P<0.05)。2组治疗后疼痛VAS、TLICS评分均降低(P<0.05),且治疗组低于对照组(P<0.05)。治疗后2组ODI评分均降低(P<0.05),且治疗组低于对照组(P<0.05);治疗后2组JOA腰痛评分均升高(P<0.05),且治疗组高于对照组(P<0.05)。治疗后2组椎体前缘丢失高度、伤椎Cobb角均降低(P<0.05),伤椎骨密度均升高(P<0.05),且治疗组改善均优于对照组(P<0.05)。治疗组并发症总发生率4.88%(2/41),对照组并发症总发生率20.51%(8/39),治疗组并发症总发生率低于对照组(P<0.05)。结论滋肾续骨汤治疗老年椎体压缩性骨折术后患者疗效显著,可有效改善临床症状及血清BMP9、VEGF水平。
Objective To observe the effect of Zishen Xugu decoction combined with salmon calcitonin on serum bone morphogenetic protein 9(BMP 9)and vascular endothelial growth factor(VEGF)in elderly patients with vertebral compression fracture after operation.Methods 80 elderly patients with vertebral compression fracture after operation were divided into two groups according to random number table method.39 cases in control group were treated by salmon calcitonin.41 cases in treatment group were treated by Zishen Xugu decoction on the basis of the control group.The curative effect was evaluated after 24 weeks of treatment in both groups.The levels of serum BMP-9,VEGF,pain visual analogue score(VAS),thoracolumbar injury classification and injury degree score system(TLICS),Oswestry dysfunction index(ODI)score,Japan Orthopedic Association(JOA)low back pain score system,and the loss height of the anterior edge of the vertebral body,injured vertebrae Cobb angle injured vertebrae bone density and complications were observed before and after treatment between two groups.Results The total effective rate was 95.12%(39/41)in treatment group and 76.92%(30/39)in control group.The clinical curative effect of the treatment group was better than that of the control group(P<0.05).After treatment,the level of serum BMP 9 and VEGF in the two groups were increased(P<0.05),and the levels in the treatment group was higher than that in the control group(P<0.05).After treatment,VAS and TLICS scores of the two groups were decreased(P<0.05),and the treatment group was lower than the control group(P<0.05).After treatment,the ODI score of the two groups was decreased(P<0.05),and the treatment group was lower than the control group(P<0.05).After treatment,the score of JOA low back pain score system in the two groups was increased(P<0.05),and the treatment group was higher than the control group(P<0.05).After treatment,the loss height of anterior edge of vertebral body,Cobb angle and bone density in the two groups were improved(P<0.05),and the loss he
作者
廖世亮
杨熹
余定华
魏炳南
韩玉卓
LIAO Shiliang;YANG Xi;YU Dinghua(Department of Orthopedics,Jiangbei District Hospital of Traditional Chinese Medicine,Chongqing 400020)
出处
《河北中医》
2020年第1期78-82,共5页
Hebei Journal of Traditional Chinese Medicine
基金
重庆市社会科学规划青年项目(编号:JX6C-29)。
关键词
椎体压缩性骨折
术后并发症
骨形态发生蛋白9
血管内皮生长因子
中西医结合疗法
Vertebral compression fracture
Postoperative complications
Bone morphogenetic protein 9
Vascular endothelial growth factor
Integrated traditional Chinese and western medicine therapy
