摘要
目的:观察术后ICU患者并发静脉血栓栓塞(VTE)的凝血功能与C-反应蛋白(CRP)变化情况,分析VTE的相关危险因素。方法:对2017年2月2019年2月本院行手术治疗后入住ICU科室的180例患者进行回顾性分析,分组的依据为是否并发VTE而分成未发生VTE的对照组(140例)与VTE组(40例),观察并比较两组患者的凝血功能与CRP变化情况,同时采用Logistic回归分析术后ICU患者并发VTE的危险因素。结果:VTE组患者凝血功能中的纤维蛋白原、D-二聚体与血清CRP分别为(5.52±0.38)g/L、(2.97±0.52)μg/L、(87.48±11.76)mg/L,均显著高于对照组的(3.74±0.60)g/L、(0.43±0.46)μg/L、(32.46±9.78)mg/L,差异有统计学意义(P<0.05);纤维蛋白原高、D-二聚体高、手术时间长、卧床时间长、有既往病史均为术后ICU患者并发VTE的独立危险因素(P<0.05)。结论:术后ICU患者并发VTE血清中的纤维蛋白原、D-二聚体及CRP显著上升,手术时间与卧床时间长,对上述相关指标应引起足够的重视,并给予合理的处理措施,以有效预防、早期发现并给予及时治疗。
Objective To observe the venous thromboembolism(VTE)in postoperative ICU patients,and to analyze the changes of coagulation function and C-reactive protein(CRP)and related risk factors.Methods A retrospective analysis of 180 patients who underwent surgery in the ICU department of our hospital from February of 2017 to February of 2019 was divided into a control group(140 patients)and a VTE group(40 patients).The coagulation function and CRP changes in each group were observed,and various risk factors of VTE were analyzed.Results The fibrinogen,D-dimer in the coagulation function and serum CRP of the VTE group were(5.52±0.38)g/L,(2.97±0.52)μg/L,and(87.48±11.76)mg/L were significantly higher than the control group(3.74±0.60)g/L,(0.43±0.46)μg/L,(32.46±9.78)mg/L(P<0.05);age,coagulation function related indicators and elevated CRP,surgery time,bedridden time,previous medical history and blood transfusion volume were independent risk factors for VTE in patients with postoperative ICU(P<0.05).Conclusion The fibrinogen,D-dimer and CRP in the serum of patients with postoperative ICU are significantly increased.The surgery time,bedridden time,past medical history and blood transfusion volume are independent risk factors.And give reasonable treatment measures to effectively prevent,early detection and treatment of postoperative ICU patients with VTE.
作者
张春梅
冉宇
孙贺元
孙静静
张畅
ZHANG Chun-mei;RAN Yu;SUN He-yuan(Department of Critical Care Medicine,Tianjin Fourth Centre Hospital,Tianjin(300140),China)
出处
《中国中西医结合外科杂志》
CAS
2020年第2期264-267,共4页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
