摘要
目的探讨小儿重症过敏性紫癜采用甲泼尼龙冲击递减疗法治疗的效果。方法选取2015年10月至2018年10月本院收治的77例过敏性紫癜患儿作为研究对象,采用随机数字表法分为对照组(n=38)和观察组(n=39)。对照组采用甲泼尼龙常规治疗,观察组采用甲泼尼龙冲击递减疗法治疗,比较两组疗效、临床指标改善情况、血清指标及不良反应发生情况。结果治疗后,观察组治疗有效率为97.4%,明显高于对照组的73.7%(P<0.05);观察组疾病症状持续时间均明显低于对照组(P<0.05);治疗前,两组血清指标比较差异无统计学意义,治疗后,观察组血清指标明显低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为10.3%,明显低于对照组的23.7%(P<0.05)。结论针对重症过敏性紫癜患儿,采用甲泼尼龙冲击递减疗法疗效显著,能缩短皮疹消退时间、关节疼痛改善时间、消化道出血改善时间,减少对肾脏的损害,改善患儿血清指标,减少不良反应,具有积极的临床推广价值。
Objective To investigate the therapeutic effect of methylprednisolone on severe allergic purpura in children.Methods 77 cases of children with allergic purpura admitted to our hospital from October 2015 to October 2018 were selected as the research subjects,and the children were divided into control group(n=38)and observation group(n=39)by random number table method.The control group received routine treatment with methylprednisolone,and the observation group received diminishing impact therapy with methylprednisolone.Results After treatment,the effective rate in the observation group was 97.4%,significantly higher than that in the control group(73.7%,P<0.05).The duration of symptoms in the observation group was significantly lower than that in the control group(P<0.05).Before treatment,there was no statistically significant difference in serum indexes between the two groups.After treatment,serum indexes of the observation group were significantly lower than those of the control group,with statistically significant difference(P<0.05).The incidence of adverse reactions in the observation group was 10.3%,significantly lower than 23.7% in the control group(P<0.05).Conclusion For children with severe anaphylactoid purpura,methylprednisolone impingement therapy has a significant curative effect,which can shorten the time to resolve the rash,improve the time of joint pain,improve the time of digestive tract bleeding,reduce the damage to the kidney,improve the serum index of children,reduce the adverse reactions,and has positive clinical promotion value.
作者
高上炎
孙延弘
李爱医
Gao Shangyan;Sun Yanhong;Li Aiyi(Department of Dermatology,Yunxi County People's Hospital,Shiyan,Hubei,442600,China)
出处
《当代医学》
2020年第13期36-38,共3页
Contemporary Medicine
关键词
过敏性紫癜
甲泼尼龙冲击递减疗法
疗效
临床指标改善
血清指标
不良反应
Allergic purpura
Methylprednisolone impact diminishing therapy
Curative effect
Improvement of clinical indicators
Serum index
Adverse reactions
