摘要
目的:分析麝香保心丸联合单硝酸异山梨酯片对冠心病患者的影响。方法:选取2014年1月至2016年12月保定市第一中心医院收治的冠心病患者143例作为研究对象,按照随机数字表法随机分为对照组(n=71)和观察组(n=72),对照组采用单硝酸异山梨酯进行常规治疗,观察组在对照组的基础上加用麝香保心丸治疗,2组均连续治疗2个月。比较2组治疗后临床疗效和不良反应发生情况;比较2组治疗前后心绞痛发作情况、血脂水平和血流变指标。结果:治疗后观察组治疗有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,2组患者心绞痛发作频率、全血黏度、血浆黏度、纤维蛋白原、血细胞比容、红细胞沉降率和总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平较治疗前降低,观察组低于对照组,发作持续时间较治疗前缩短,观察组低于对照组,差异有统计学意义(P<0.05);2组血清高密度脂蛋白胆固醇(HDL-C)水平升高,观察组高于对照组,差异有统计学意义(P<0.05);2组间不良反应发生率比较,差异无统计学意义(P>0.05)。结论:麝香保心丸联合单硝酸异山梨酯片治疗冠心病疗效显著,可有效改善患者心绞痛发作情况与血脂水平,同时改善其血流变。
Objective:To investigate the effects of Shexiang Baoxin Pills combined with isosorbide mononitrate on blood lipids and blood rheology in patients with coronary heart disease and its safety.Methods:A total of 143 cases patients with coronary heart disease in Baoding First Central Hospital from January 2014 to December 2016 were selected as study objects and were divided randomly into a test group(n=72)and a control group(n=71).The control group was treated with isosorbide mononitrate(1 tablet·time-1,3 times·d-1),and the test group was treated with Shexiang Baoxin Pill(1 pill·time-1,3 times·d-1)on the basis of control group.The 2 groups were treated consecutively for 2 months.The clinical efficacy of 2 groups were compared after treatment;the occurrence of angina pectoris of 2 groups was counted;the total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and hemorheology indexes of 2 groups were detected and compared before and after treatment;the incidence rates of adverse reactions of 2 groups were compared.Results:After treatment,the clinical efficacy of test group was 95.83%,which was higher than 69.01%in the control group(P<0.01);Ccompared with that before treatment,the frequency of angina pectoris in 2 groups decreased,and the occurrence duration of 2 groups shortened,and there was obvious difference between 2 groups(P<0.01);compared with those before treatment,the serum TC,TG,LDL-C levels of 2 groups decreased after treatment,and test group was lower than control group;the serum HDL-C levels of 2 groups increased after treatment,and test group was higher than control group(P<0.05 or P<0.01);compared with those before treatment,the whole blood viscosity,plasma viscosity,fibrinogen,hematocrit,erythrocyte sedimentation of 2 groups decreased after treatment,and test group was lower than control group(P<0.05 or P<0.01);there were no obvious difference between 2 groups on the incidence rate of adverse reactions(P>0.05).Conclusion:Shexiang Bao
作者
王辉
赵剑斌
文雪花
李鼎
WAGN Hui;ZHAO Jianbin;WEN Xuehua;LI Ding(Department of Pharmacy, the first Central Hospital of Baoding City, Baoding 071000, China;Department of Surgery and Anesthesiology, Affiliated Hospital of Hebei University, Baoding 071000, China)
出处
《世界中医药》
CAS
2020年第7期1051-1054,共4页
World Chinese Medicine
基金
河北省医学科学研究重点课题计划项目(20181488)。
关键词
冠心病
麝香保心丸
单硝酸异山梨酯片
血脂
血液流变学
Coronary heart disease
Shexiang baoxin pill
Isosorbide mononitrate
Blood lipid
Hemorheology
