摘要
高迁移率族蛋白B1(high mobility group protein B1,HMGB1)是重要的损伤相关分子,由凋亡、坏死细胞及激活的巨噬细胞、树突状细胞等可被动或主动释放,通过核因子κB(nuclear factor kappa-B,NF-κB)等信号通路诱导肿瘤坏死因子α(tumor necrosis factorα,TNF-α)、白细胞介素(interleukin,IL)-6等炎症因子分泌,而致炎因子又可促进HMGB1的释放,从而形成正反馈环路通路,启动、维持及放大炎症反应。本综述总结了HMGB1的结构、功能及在新生儿脑损伤中的研究进展。
High mobility group protein B1(HMGB1) is an important injury-related molecule that can be passively or actively released by apoptosis cells, necrotic cells and activated macrophages, dendritic cells, etc. It also can activate inflammatory signaling pathways such as nuclear factor kappa-B(NF-κB) pathway to induce inflammatory factors such as tumor necrosis factor-α(TNF-α) and interleukin(IL)-6, and these factors can promote the release of HMGB1 in turn, which forms a positive feedback loop pathway that initiates, maintains, and amplifies the inflammatory response. This review summarizes the structure, function, and research progress of HMGB1 in neonatal brain injury.
作者
黄铧
赵建美
HUANG Hua;ZHAO Jianmei(Department of Pediatrics,the Affiliated Hospital of Nantong University,Nantong 226001)
出处
《南通大学学报（医学版）》
2020年第1期55-58,共4页
Journal of Nantong University(Medical sciences)
基金
江苏省研究生科研与实践创新计划项目(SJCX18-0821)。
