摘要
脑缺血/再灌注损伤(cerebral ischemia/reperfusion injury,CI/RI)是脑卒中患者血栓再通后常见的临床病理生理现象,其发病机制涉及多个环节,其中线粒体作为"能量站"扮演了关键角色。缺血性脑卒中诱导脑内大量微RNA(microRNAs,miRNAs)和长链非编码RNA(long non-coding RNAs,lncRNAs)的表达改变,提示miRNAs和lncRNAs与缺血性脑卒中复杂的病理过程有关。此外,研究发现相关miRNAs和lncRNAs可通过调节线粒体参与CI/RI的发生、发展过程。文章综述线粒体在CI/RI中的作用,以及miRNAs和lncRNAs调节线粒体参与CI/RI的最新研究进展,旨在从miRNAs和lncRNAs水平探讨线粒体调控CI/RI的机制,为CI/RI的防治提供新的靶点和思路。
Cerebral ischemia/reperfusion injury(CI/RI)is a common clinical pathophysiological phenomenon after thrombus recanalization in stroke patients.Its pathogenetic mechanism involves multiple steps,of which mitochondria play a key role as"energy stations".Cerebral ischemic stroke induces remarkable changes in the expression of microRNAs(miRNAs)and long non?coding RNAs(lncRNAs)in the brain,which indicates the association of miRNAs and lncRNAs of the complex pathological process after ischemic stroke.In addition,some related miRNAs and lncRNAs are found to participate in the development of CI/RI by regulating mitochondria.The current review is designed to summarize the effects of mitochondria on CI/RI,and the latest research findings about the involvement of miRNAs and lncRNAs to regulate CI/RI,so as to provide new targets and ideas for the prevention and treatment of CI/RI,as well as new thoughts and ideas for the prevention and treatment of CI/RI.
作者
唐亚男
张倩
张高峰
陈怀龙
孙晓鹏
时飞
王明山
Tang Yanan;Zhang Qian;Zhang Gaofeng;Chen Huailong;Sun Xiaopeng;Shi Fei;Wang Mingshan(Department of Anesthesiology,the Affiliated Qingdao Municipal Hospital of Qingdao University,Qingdao 266071,China)
出处
《国际麻醉学与复苏杂志》
CAS
2020年第1期111-115,共5页
International Journal of Anesthesiology and Resuscitation
基金
山东省自然科学基金(ZR2015HM023)
青岛市市南区科技项目(2016?3?029?YY)。
