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帕罗西汀联合奥氮平治疗老年精神分裂症伴抑郁的效果及不良反应率分析 被引量:8

Efficacy and Adverse Reaction Rate of Paroxetine combined with Olanzapine in the Treatment of Senile Schizophrenia with Depression
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摘要 目的探索帕罗西汀联合奥氮平治疗老年精神分裂症伴抑郁的效果及不良反应率。方法选取2017年4月21日至2018年4月21日期间我院老年精神分裂症伴抑郁100例患者,实施奇偶数分组模式随机分为对照组和观察组,各50例,对照组的50例患者进行帕罗西汀治疗,观察组的50例患者进行帕罗西汀联合奥氮平治疗。结果观察组治疗后15 d、治疗后30 d、治疗后60 d SAS评分以及SDS评分恢复情况均优于对照组(P<0.05),同时阳性症状(11.86±1.41)分、阴性症状(12.58±1.39)分、精神病理(13.79±1.52)分、PANSS总分(36.17±5.22)分、不良反应发生率(4.00%)低于对照组(P<0.05)。结论对老年精神分裂症伴抑郁患者实施帕罗西汀联合奥氮平治疗效果明显。 Objective To explore the effi cacy and adverse reaction rate of paroxetine combined with olanzapine in the treatment of senile schizophrenia with depression.Methods 100 elderly schizophrenic patients with depression from April 21,2017 to April 21,2018 were randomly divided into control group and observation group,50 cases in each group,50 cases in control group were treated with paroxetine,50 cases in observation group were treated with paroxetine combined with olanzapine.Results The recovery of SAS scores and SDS scores in the observation group at 15 d,30 d,and 60 d after treatment were better than those in the control group(P<0.05).At the same time,the scores of positive symptoms(11.86±1.41)and negative symptoms(12.58±1.39),Psychopathology(13.79±1.52),total PANSS score(36.17±5.22),and the incidence of adverse reactions(4.00%)were lower than those in the control group(P<0.05).Conclusion Paroxetine combined with olanzapine is effective in the treatment of senile schizophrenia with depression.
作者 崔淑敏 CUI Shu-min(Department of Pharmacy,Jilin Neuropsychiatry Hospital,Siping 136000,China)
出处 《中国医药指南》 2020年第10期145-146,共2页 Guide of China Medicine
关键词 帕罗西汀 奥氮平 精神分裂症 抑郁 不良反应 Paroxetine Olanzapine Schizophrenia Depression Adverse reactions
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