摘要
目的探讨静脉应用丙种球蛋白对百日咳患儿血清免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)水平的影响。方法选取南京市第二医院2017年1月至2019年6月收治的80例百日咳患儿,采用数表法随机分为对照组和观察组,各40例。对照组给予常规治疗,观察组在其基础上给予丙种球蛋白静脉注射,2组均治疗7d。比较2组治疗后临床疗效、痉挛性咳嗽改善情况、不良反应发生率,及2组治疗前后免疫球蛋白指标。结果与对照组相比,治疗后观察组临床总有效率为95.00%,高于对照组的80.00%(P<0.05);治疗后观察组痉挛性咳嗽改善情况优于对照组(P<0.05);与治疗前相比,治疗后2组的IgG、IgA、IgM水平均升高,且观察组高于对照组(P<0.05);观察组不良反应发生率为5.00%,高于对照组的2.50%,但差异无统计学意义(P>0.05)。结论丙种球蛋白静脉注射治疗百日咳患儿疗效及症状缓解显著,并可调节其免疫功能。
Objective To explore the effect of intravenous immunoglobulin on the level of serum IgG,IgA and IgM in children with pertussis.Methods Totally 80 cases of pertussis in Nanjing Second Hospital from January 2017 to June 2019 were randomly divided into control group and observation group,40 cases each.The control group was given routine treatment,the observation group was given intravenous injection of gamma globulin on the basis of the treatment,both groups were treated for 7 days.The clinical effect,improvement of spasmodic cough,incidence of adverse reactions and immunoglobulin before and after treatment were compared between the two groups.Results Compared with the control group,the total clinical effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group(P<0.05);compared with the control group,the improvement of spastic cough in the observation group was better than that in the control group(P<0.05);the levels of IgG,IgA and IgM in the observation group were higher than those in the control group(P<0.05);the incidence of adverse reactions in the observation group was 5.00%,which was higher than 2.50%in the control group,but the difference was not statistically significant(P>0.05).Conclution Intravenous injection of gamma globulin in the treatment of pertussis in children with significant efficacy and symptom relief,regulating its immune function.
作者
龚蕾
GONG Lei(Nanjing Second Hospital,Nanjing,Jiangsu 210000,China)
出处
《大医生》
2019年第22期156-158,共3页
Doctor
关键词
百日咳
丙种球蛋白
静脉注射
免疫球蛋白
pertussis
gamma globulin
intravenous injection
immunoglobulin
