摘要
对1例发生于阴茎的上皮样肉瘤样血管内皮瘤进行常规HE染色、免疫组化染色及荧光原位杂交,观察其结果并结合既往文献分析。组织病理表现HE下呈成片或模糊结节状上皮样细胞或梭形细胞组成,缺乏血管内皮分化的特征,免疫组化一般表现为:AE1/AE3(+)、ERG(+)、FLI-1(+)、INI-1无缺失、CD31表达不恒定、CD34(-)、desmin(-),部分患者免疫组化FOSB可阳性或荧光原位杂交检测到t(7,19)(q22,q13)/SERP1NE1-FOSB,需要与上皮样肉瘤,上皮样血管内皮瘤等鉴别。上皮样肉瘤样血管内皮瘤是少见的软组织肿瘤,发生于阴茎罕见,HE下常不能诊断,需要免疫组化确诊,基因检测可辅助诊断,虽然大部分报道该病为隐匿性病程,但仍有极少数发生转移,早期诊断及长期随访很重要。
The clinicopathological characteristics,histopathological examination,immunohistoc-hemistry stain and fluorescence in situ hybridization of one case of penile epithelioid sarcoma-like hemangioendothelioma were invesgated.The relevant literature were reviewed as well.The histopathological examination showed that it was composed of patchy or blurred nodular epithelioid cells or spindle cells and lacked the characteristics of vascular endothelial differentiation.Immunohistochemistry stain showed that AE1/AE3(+),ERG(+),FLI1(+),INI-1(+),CD31 expression was not constant,CD34(-),desmin(-),some patients immunohistochemical FOSB could be positive or fluorescence in situ hybridization detected t(7,19)(q22,q13)/SERP1 NE1-FOSB.It was necessary to be differentiated from epithelioid sarcoma,epithelioid hemangioendothelioma.Epithelioid sarcoma-like hemangioendothelioma is a rare malignant tumor,especially in the penis.It could not be diagnosed under HE.It needs immunohistochemistry to confirm the diagnosis.Gene detection can assist the diagnosis.Although most reports indicate that the tumor is indolent,a few metastases still occur.Early diagnosis and longterm follow-up are very important.
作者
宋黎
王雷
SONG Li;WANG Lei(Department of Dermatology,Xijing Hospital,the Fourth Military Medical University,Xi'an 710032,China;Department of Dermatology,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2020年第4期430-434,共5页
The Chinese Journal of Dermatovenereology
关键词
上皮样肉瘤样血管内皮瘤
假肌源性
免疫组织化学
Epithelioid sarcoma-like hemangioendothelioma
Pseudomyogenic
Immunohistochemical
