摘要
表观遗传学指独立于DNA核苷酸序列本身的基因表达的可遗传改变,其主要机制包括DNA甲基化、组蛋白修饰和非编码RNA等,这些机制共同作用调控基因的特异性表达。血管疾病是由环境因素和遗传因素相互作用引发的一种慢性疾病。近年来,越来越多的研究证实表观遗传调节在血管疾病的发生发展中具有重要的作用。本文对表观遗传学在血管疾病中的最新研究进展进行综述。
Epigenetics refers to heritable changes in gene expression independent of DNA nucleotide sequence itself,and the main mechanisms include DNA methylation,histone modifications,noncoding RNAs,and so on.Vascular disease is a chronic disease regulated by the interaction between environmental and genetic factors.In recent years,more and more studies have confirmed that epigenetic regulation plays an important role in the occurrence and development of vascular diseases.This article reviews recent advances in epigenetics in vascular disease.
作者
李东泽
李芳卉
曾锐
曹钰
万智
LI Dongze;LI Fanghui;ZENG Rui;CAO Yu;WAN Zhi(Department of Emergency Medicine,West China Hospital,Sichuan University,Chengdu,610041,P.R.China;Disaster Medical Center,Sichuan University,Chengdu,610041,P.R.China;Department of Cardiology,West China Hospital,Sichuan University,Chengdu,610041,P.R.China)
出处
《中国胸心血管外科临床杂志》
CAS
CSCD
2020年第4期471-475,共5页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
基金
国家重点研发项目(2017YFC0908702)
四川省科学技术项目(2019JDRC0105,2018RZ0139,2017SZ0190)
成都市科技惠民项目(2016-HM02-00099-SF)
四川大学华西医院学科卓越发展1·3·5工程临床研究孵化项目(2018HXFH001,2018HXFH027)。
