摘要
目的:探讨盐酸美金刚治疗帕金森病痴呆的临床效果。方法:选取收治的94例帕金森病痴呆患者为研究对象,采用随机数字表法分为对照组和观察组,每组47例。对照组予多巴丝肼与多奈哌齐治疗,观察组予多巴丝肼与盐酸美金刚药物治疗,比较两组患者治疗前后相关量表评分及神经与炎性因子水平。结果:治疗后,两组日常生活活动量表(ADL)、简易智力状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分均高于治疗前,帕金森综合评分量表(UPDRS)评分低于治疗前,且观察组ADL、MMSE及MoCA评分均高于对照组,UPDRS评分低于对照组,差异均有统计学意义(P<0.05)。两组重组人帕金森病蛋白7(PARK7)、C反应蛋白(CRP)水平均低于治疗前,神经营养因子3(NT-3)水平高于治疗前,且观察组PARK7和CRP水平低于对照组,NT-3水平高于对照组,差异均有统计学意义(P<0.05)。结论:盐酸美金刚在改善帕金森痴呆患者认知功能中具有显著疗效,同时能够提升患者的日常生活水平,改善神经与炎性因子水平。
Objective:To explore clinical effects of Memantine hydrochloride in treatment of Parkinson’s disease and dementia.Methods:94 patients with Parkinson’s disease and dementia were selected as the research subjects,and were divided into control group and observation group by using the random number table method,47 cases in each group.The control group was treated with Levodopa and Benserazide hydrochloride combined with Donepezil,while the observation group was treated with Levodopa and Benserazide hydrochloride and Memantine hydrochloride.The scores of related scales and the levels of neurological and inflammatory factors were compared between the two groups before and after the treatment.Results:After the treatment,the scores of the activity of daily living scale(ADL),mini mental state examination(MMSE),and the Montreal cognitive assessment scale(MoCA)of the two groups were higher than those before the treatment;however,the scores of the unified Parkinson’s disease rating scale(UPDRS)were lower than those before the treatment;and the differences were statistically significant(P<0.05).The scores of ADL,MMSE and MoCA of the observation group were higher than those of the control group,the score of UPDRS was lower than that of the control group,and the differences were statistically significant(P<0.05).The levels of recombinant human Parkinson’s disease related protein 7(PARK7)and C-reactive protein(CRP)in the two groups were lower than those before the treatment,the neurotrophic factor 3(NT-3)levels were higher than those before the treatment,and the differences were statistically significant(P<0.05).The levels of PARK7 and CRP in the observation group were lower than those in the control group,the NT-3 level was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Memantine hydrochloride has a significant effect in improving the cognitive function in the patients with Parkinson’s disease and dementia,and can improve the patients’daily living level and
作者
刘亚
LIU Ya(The First People’s Hospital of Yueyang City,Yueyang 414000 Hunan,China)
出处
《中国民康医学》
2020年第4期13-15,共3页
Medical Journal of Chinese People’s Health
关键词
盐酸美金刚
帕金森病痴呆
认知功能
Memantine hydrochloride
Parkinson’s disease and dementia
Cognitive function
