摘要
本研究对细菌中的两个双组分系统(RaxH/RaxR与RavA/RavR)之间及其自身两个蛋白之间是否具有共进化特征进行了分析,发现其存在高度的共进化关系,预示它们之间在信号传导中可能处于某一传导途径的不同节点.通过遗传分析发现,RaxH/RaxR在转录水平上调控ravA/ravR的表达,应位于RavA/RavR信号传递的上游.由于RaxH/RaxR可能感应和传导群体信号,而RavA/RavR又调控细胞第二信使c-di-GMP的代谢,所以此双组分级联系统可能在细菌群体行为中扮演重要的角色.
In the report,the co-evolution analysis of two TCSTSs:RaxH/RaxR and RavA/RavR,and the two proteins of themselves,were performed.The results indicated that there are high co-evolution relationship between them,which suggest that the two TCSTSs may belong to the same signal pathway.The further analysis showed that RaxH/RaxR might locate at the upstream of RavA/RavR in the virulence-related signaling pathways.Because RaxH/RaxR not only can sense and conduct population signal,but also regulate the metabolism of c-di-GMP,the signaling cascade of RaxH/RaxR and RavA/RavR might play important roles in quorum sensing of bacteria.
作者
李婷
林玉暖
林茂娟
牛晓磊
李春霞
陈银华
陶均
Li Ting;Lin Yunuan;Lin Maojuan;Niu Xiaolei;Li Chunxia;Chen Yinhua;Tao Jun(Hainan Key Laboratory for Sustainable Utilization of Tropical Bioresources, College of Tropical Crops, Hainan University, Haikou 570228, China)
出处
《海南大学学报（自然科学版）》
CAS
2020年第1期46-51,共6页
Natural Science Journal of Hainan University
基金
国家自然科学基金(31660507)
海南省研究生创新科研课题项目(Hys2018-01)
海南大学科研启动基金(kyqd1546)。
