摘要
目的 探讨脂肪乳联合碳酸氢钠治疗急性重度有机磷农药中毒的临床疗效.方法 选取2017年1月~2019年5月在医院诊断治疗的急性重度有机磷农药中毒的患者120例为研究对象,随机分为观察组与对照组,各60例.两组均给予常规急救治疗.观察组在此基础上给予脂肪乳联合碳酸氢钠治疗.比较两组达阿托品化时间,机械通气时间以及住院天数,治疗后胆碱酯酶活力水平,动脉血pH值,HCO3-水平.结果 (1)观察组阿托品化时间、机械通气时间以及住院时间均显著短于对照组,差异有统计学意义(P<0.05).(2)治疗后,两组胆碱酯酶活力均呈迅速升高的趋势,与入组时比较,差异有统计学意义(P<0.05);治疗3d及治疗5、7d,观察组胆碱酯酶活力水平显著高于对照组,差异有统计学意义(P<0.05).(3)治疗后两组动脉血pH值以及HCO3-水平均较入组时显著升高,差异有统计学意义(P<0.05);治疗后,观察组动脉血pH值以及HCO3-水平显著高于对照组,差异有统计学意义(P<0.05).(4)观察组阿托品总用量及氯磷定总用量显著低于对照组,差异有统计学意义(P<0.05).结论 在常规治疗基础上给予脂肪乳联合碳酸氢钠治疗急性重度有机磷农药中毒可显著提高胆碱酯酶活力水平,缩短阿托品化时间、机械通气时间以及住院时间.
Objective To investigate the clinical efficacy of lipid emulsion combined with sodium bicarbonate in the treatment of acute severe organophosphorus pesticide poisoning.Methods 120 patients with acute severe organophosphorus pesticide poisoning diagnosed and treated in our hospital from January 2017 to May 2019 were selected as the research subjects,and were randomly divided into the observation group and the control group,with 60 cases in each group.Both groups were given routine emergency treatment,while the observation group was given lipid emulsion combined with sodium bicarbonate on the basis of this.The time of atropinization conversion,the time of mechanical ventilation,and the length of hospital stay,the levels of cholinesterase activity,arterial blood pH,and HCO3-levels were compared between the two groups.Results(1)The atropine time,mechanical ventilation time,and hospital stay of the observation group were significantly shorter than those of the control group,and the differences were statistically significant(P<0.05).(2)After treatment,the activity of cholinesterase in both groups showed a rapid increase trend,as compared with that before treatment,and the difference was statistically significant(P<0.05).The activity of cholinesterase at 3,5 and 7 days after treatment in the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).(3)After treatment,the arterial blood pH and HCO3-levels in both groups were significantly higher than those before treatment,and the differences were statistically significant(P<0.05);after treatment,the arterial blood pH and HCO3-levels in the observation group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).(4)The total dosage of atropine and pralidoxime chloride in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Lipid emulsion combined w
作者
范杰
FAN Jie(Chifeng Hospital of Inner Mongolia Autonomous Region,Inner Mongolia,Chifeng 024000,China)
出处
《中国医药科学》
2020年第6期43-46,共4页
China Medicine And Pharmacy
关键词
脂肪乳
碳酸氢钠
有机磷农药中毒
阿托品化
胆碱酯酶活力
Lipid emulsion
Sodium bicarbonate
Organophosphorus pesticide poisoning
Atropine
Cholinesterase activity
